Whipple-kór. Vajon gondolunk-e mindig rá?

Tünde Fischer, Márta Tiboly, Péter Tóth, Mária Szenes, Zoltán Völgyi, Otília Bali, B. Gasztonyi

Research output: Article

Abstract

Whipple's disease is a chronic, systemic, relapsing bacterial illness, which is always fatal without treatment, and means a diagnostic challenge for both clinicians and pathologists. It occurs in Caucasian, white, middle-aged men in 80 % of the cases. Case report: The authors present three cases, and review the etiology, clinical features, presumed pathomechanism and the possibilities of treatment. Conclusion: Several immune-mechanisms have been discussed in the background of Whipple's disease, but their primary or secondary role is yet undetermined. First of all, this is a gastrointestinal disease; however, extraintestinal symptoms may be present many years before the final diagnosis. The histological hallmark for the diagnosis is the presence of numerous macrophages in the duodenal mucosa showing periodic acid-Schiff (PAS)-positive inclusions, and the polymerase chain reaction. The choice of antibiotics and the length of the treatment is empiric, but in most cases there is an immediate response to therapy. Relapses are common, especially the involvements of central nervous system.

Original languageHungarian
Pages (from-to)1313-1319
Number of pages7
JournalOrvosi Hetilap
Volume150
Issue number28
DOIs
Publication statusPublished - júl. 1 2009

Fingerprint

Whipple Disease
Periodic Acid
Gastrointestinal Diseases
Therapeutics
Mucous Membrane
Central Nervous System
Macrophages
Anti-Bacterial Agents
Recurrence
Polymerase Chain Reaction

Keywords

  • Lymph node enlargement
  • Malabsorption syndromes
  • Positive PAS stain
  • Whipples disease

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fischer, T., Tiboly, M., Tóth, P., Szenes, M., Völgyi, Z., Bali, O., & Gasztonyi, B. (2009). Whipple-kór. Vajon gondolunk-e mindig rá? Orvosi Hetilap, 150(28), 1313-1319. https://doi.org/10.1556/OH.2009.28668

Whipple-kór. Vajon gondolunk-e mindig rá? / Fischer, Tünde; Tiboly, Márta; Tóth, Péter; Szenes, Mária; Völgyi, Zoltán; Bali, Otília; Gasztonyi, B.

In: Orvosi Hetilap, Vol. 150, No. 28, 01.07.2009, p. 1313-1319.

Research output: Article

Fischer, T, Tiboly, M, Tóth, P, Szenes, M, Völgyi, Z, Bali, O & Gasztonyi, B 2009, 'Whipple-kór. Vajon gondolunk-e mindig rá?', Orvosi Hetilap, vol. 150, no. 28, pp. 1313-1319. https://doi.org/10.1556/OH.2009.28668
Fischer T, Tiboly M, Tóth P, Szenes M, Völgyi Z, Bali O et al. Whipple-kór. Vajon gondolunk-e mindig rá? Orvosi Hetilap. 2009 júl. 1;150(28):1313-1319. https://doi.org/10.1556/OH.2009.28668
Fischer, Tünde ; Tiboly, Márta ; Tóth, Péter ; Szenes, Mária ; Völgyi, Zoltán ; Bali, Otília ; Gasztonyi, B. / Whipple-kór. Vajon gondolunk-e mindig rá?. In: Orvosi Hetilap. 2009 ; Vol. 150, No. 28. pp. 1313-1319.
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