Wettability of biodegradable surfaces

E. I. Vargha-Butler, E. Kiss, C. N C Lam, Z. Keresztes, E. Kálmán, L. Zhang, A. W. Neumann

Research output: Article

29 Citations (Scopus)

Abstract

The study of the interfacial characteristics of biodegradable polymers/copolymers is of importance from the point of view of both surface science and pharmaceutical/ cosmetic applications. Films formed from biodegradable polymers allow systematic wettability studies on surfaces with a wide range of copolymer (chemical) compositions. The possibility of interchanging these drug carrier polymers, if their wetting characteristics are similar, could be beneficial to diverse applications. Low-rate dynamic contact angles on films (solvent cast on polar substrates, i.e. on silicon wafer) of poly(lactic acid), and its copolymers with poly(glycolic acid), (with four different copolymer ratios of 85/15, 75/25, 65/35 and 50/50) were measured by axisymmetric drop shape analysis-profile (ADSA-P) with four liquids: water, formamide, 2,2′-thiodiethanol and 3-pyridylcarbinol. The solid surface tensions, γSV, were calculated from the advancing contact angles. θA. The surface topography of the polymer films was investigated by atomic force microscopy (AFM). The surface composition of the polymer layers was analyzed by X-ray photoelectron spectroscopy (XPS). The advancing contact angles were found to be independent of the composition of the copolymers, while the receding angles. θR, did decrease with increasing ratio of the polar component [poly(glycolic acid)] in the copolymers. The solid surface tensions calculated from the advancing contact angles of the liquids for all homo- and copolymers were the same within the error limit; the mean value being γSV = 35.6 ± 0.2 mJ/m2. The surface roughness, which was obtained from AFM images, increased with increasing poly(glycolic acid) ratio, without affecting the advancing contact angles. The constancy of γSV is attributed to the effect of the surface activity of the nonpolar segments of the polymer chains, which oriented to form the outermost layer of the film. This was confirmed by XPS analysis.

Original languageEnglish
Pages (from-to)1160-1168
Number of pages9
JournalColloid & Polymer Science
Volume279
Issue number12
DOIs
Publication statusPublished - dec. 2001

Fingerprint

wettability
glycolic acid
Wetting
copolymers
Copolymers
Contact angle
polymers
Polymers
Biodegradable polymers
solid surfaces
acids
Surface tension
Acids
Nicotinyl Alcohol
Atomic force microscopy
interfacial tension
X ray photoelectron spectroscopy
photoelectron spectroscopy
atomic force microscopy
Drug Carriers

ASJC Scopus subject areas

  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Vargha-Butler, E. I., Kiss, E., Lam, C. N. C., Keresztes, Z., Kálmán, E., Zhang, L., & Neumann, A. W. (2001). Wettability of biodegradable surfaces. Colloid & Polymer Science, 279(12), 1160-1168. https://doi.org/10.1007/s003960100549

Wettability of biodegradable surfaces. / Vargha-Butler, E. I.; Kiss, E.; Lam, C. N C; Keresztes, Z.; Kálmán, E.; Zhang, L.; Neumann, A. W.

In: Colloid & Polymer Science, Vol. 279, No. 12, 12.2001, p. 1160-1168.

Research output: Article

Vargha-Butler, EI, Kiss, E, Lam, CNC, Keresztes, Z, Kálmán, E, Zhang, L & Neumann, AW 2001, 'Wettability of biodegradable surfaces', Colloid & Polymer Science, vol. 279, no. 12, pp. 1160-1168. https://doi.org/10.1007/s003960100549
Vargha-Butler, E. I. ; Kiss, E. ; Lam, C. N C ; Keresztes, Z. ; Kálmán, E. ; Zhang, L. ; Neumann, A. W. / Wettability of biodegradable surfaces. In: Colloid & Polymer Science. 2001 ; Vol. 279, No. 12. pp. 1160-1168.
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