Volume changes in intra- and extraorbital compartments in patients with Graves' ophthalmopathy: Effect of smoking

Zsolt Szucs-Farkas, Judit Toth, J. Kollár, L. Galuska, Kenneth D. Burman, Judit Boda, Andras Leovey, J. Varga, Bernadett Ujhelyi, Jeno Szabo, A. Berta, E. Nagy

Research output: Article

16 Citations (Scopus)

Abstract

The objective of this study was to demonstrate the effect of smoking history on soft tissue expansion in specific orbital compartments in patients with Graves' ophthalmopathy. The volumes of the rectus muscles, intra- and extraorbital connective, and soft tissues were measured in 110 orbits of 35 patients and 20 control subjects. Data sets from current smokers, ex-smokers, and non-smokers were compared. The total number of cigarettes smoked was calculated, and it was used as an estimate for the severity of smoking (cumulative smoking). The volume measurements were performed on T1-weighted contiguous transversal magnetic resonance images of the orbits. Connective tissue volumes were influenced by smoking history, while muscle volumes were not affected. Ex-smokers had larger amount of extraorbital connective tissue than current smokers (p = 0.012), and this volume showed a good correlation with the number of cigarettes smoked (r = 0.539, p <0.05). In current smokers, the amount of intraorbital connective tissue correlated well with the cumulative smoking (r = 0.635, p <0.001) We conclude that connective tissue volumes in certain orbital compartments correlate well with cumulative smoking. Extraocular muscle volumes are not influenced by smoking in patients with Graves' ophthalmopathy.

Original languageEnglish
Pages (from-to)146-151
Number of pages6
JournalThyroid
Volume15
Issue number2
DOIs
Publication statusPublished - febr. 2005

Fingerprint

Graves Ophthalmopathy
Smoking
Connective Tissue
Orbit
Tobacco Products
Oculomotor Muscles
History
Tissue Expansion
Muscles
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Endocrinology

Cite this

Volume changes in intra- and extraorbital compartments in patients with Graves' ophthalmopathy : Effect of smoking. / Szucs-Farkas, Zsolt; Toth, Judit; Kollár, J.; Galuska, L.; Burman, Kenneth D.; Boda, Judit; Leovey, Andras; Varga, J.; Ujhelyi, Bernadett; Szabo, Jeno; Berta, A.; Nagy, E.

In: Thyroid, Vol. 15, No. 2, 02.2005, p. 146-151.

Research output: Article

Szucs-Farkas, Zsolt ; Toth, Judit ; Kollár, J. ; Galuska, L. ; Burman, Kenneth D. ; Boda, Judit ; Leovey, Andras ; Varga, J. ; Ujhelyi, Bernadett ; Szabo, Jeno ; Berta, A. ; Nagy, E. / Volume changes in intra- and extraorbital compartments in patients with Graves' ophthalmopathy : Effect of smoking. In: Thyroid. 2005 ; Vol. 15, No. 2. pp. 146-151.
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