Vinpocetin alkalmazása neurológiai kórképekben

László Szapáry, Gábor Késmárky, Kálmán Tóth, Melinda Misnyovszky, Tamás Tóth, Ádám Balogh, Krisztián Nagy, György Németh, Gergely Fehér

Research output: Review article

5 Citations (Scopus)

Abstract

Introduction - Stroke is the third leading cause of death worldwide (following cardiovascular and cancer mortality) and associated with serious disability for the vast majority of patients. There is no salvage therapy for irreversibly damaged brain areas, improving the circulation of the surrounding hypoperfused territories may be associated with benefitial clinical states. Cerebral hypoperfusion may play a role in the pathogenesis of other kind of neurological diseases, improvement of global circulation may have a preventive effect on these conditions. Aims - The aim of our study was to review the experimental and clinical articles focusing on the role of vinpocetin in different neurological conditions. Results - Vinpocetin appears to have several different mechanisms of action that allow for its antiinflammatory, antioxidant, vasodilating, antiepileptic and neuroprotective activities in experimental conditions. On the other hand, several meta-analysis of the existing studies in acute stroke examining short and long term fatality rates with vinpocetin was unable to assess efficacy. In chronic cerebrovascular patients, vinpocetin improves impaired hemorheological variables, has significant vasodilating properties, improves endothelial dysfunction, neuroimaging studies showed selective increase in cerebral blood flow and cerebral metabolic rate, all of which are potentially beneficial in cerebrovascular disease and may improve cognitive functions. Summary - Based on the above mentioned results vinpocetin plays an important role both in basic research and in clinical management of different neurological diseases.

Translated title of the contributionVinpocetin in neurological diseases
Original languageHungarian
Pages (from-to)387-393
Number of pages7
JournalIdeggyogyaszati szemle
Volume65
Issue number11-12
Publication statusPublished - nov. 30 2012

Keywords

  • Antioxidant
  • Cerebrovascular disease
  • Hemorheology
  • Neuroprotection
  • Review article
  • Signal transduction pathways
  • Vinpocetin

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Szapáry, L., Késmárky, G., Tóth, K., Misnyovszky, M., Tóth, T., Balogh, Á., Nagy, K., Németh, G., & Fehér, G. (2012). Vinpocetin alkalmazása neurológiai kórképekben. Ideggyogyaszati szemle, 65(11-12), 387-393.