Value of delayed-enhancement cardiovascular magnetic resonance imaging in predicting myocardial viability after surgical revascularization

Joseph B. Selvanayagam, A. Kardos, Jane M. Francis, Frank Wiesmann, Steffen E. Petersen, David P. Taggart, Stefan Neubauer

Research output: Article

232 Citations (Scopus)

Abstract

Background - Despite the accepted utility of delayed-enhancement MRI in identifying irreversible myocardial injury, no study has yet assessed its role as a viability tool exclusively in the setting of coronary artery bypass surgery (CABG), and no study has repeated delayed-enhancement MRI late after revascularization. In a clinical trial in which patients underwent CABG by either the off-pump or on-pump surgical technique, we hypothesized that (1) preoperative delayed-enhancement MRI would have high diagnostic accuracy in predicting viability and (2) the occurrence of perioperative myocardial necrosis would affect late regional wall motion recovery. Methods and Results - Fifty-two patients undergoing multivessel CABG were studied by preoperative and early (day 6) and late (6 months) postoperative cine MRI for global and regional functional assessment and delayed-enhancement MRI for assessment of irreversible myocardial injury. Preoperatively, 611 segments (21%) had abnormal regional function, whereas 421 segments (14%) showed evidence of hyperenhancement. At 6 months after revascularization, 57% (343 of 611) of dysfunctional segments improved contraction by at least 1 grade. When all preoperative dysfunctional segments were analyzed, there was a strong correlation between the transmural extent of hyperenhancement and the recovery in regional function at 6 months (P

Original languageEnglish
Pages (from-to)1535-1541
Number of pages7
JournalCirculation
Volume110
Issue number12
DOIs
Publication statusPublished - szept. 21 2004

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Coronary Artery Bypass
Magnetic Resonance Imaging
Cine Magnetic Resonance Imaging
Wounds and Injuries
Necrosis
Clinical Trials

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Value of delayed-enhancement cardiovascular magnetic resonance imaging in predicting myocardial viability after surgical revascularization. / Selvanayagam, Joseph B.; Kardos, A.; Francis, Jane M.; Wiesmann, Frank; Petersen, Steffen E.; Taggart, David P.; Neubauer, Stefan.

In: Circulation, Vol. 110, No. 12, 21.09.2004, p. 1535-1541.

Research output: Article

Selvanayagam, Joseph B. ; Kardos, A. ; Francis, Jane M. ; Wiesmann, Frank ; Petersen, Steffen E. ; Taggart, David P. ; Neubauer, Stefan. / Value of delayed-enhancement cardiovascular magnetic resonance imaging in predicting myocardial viability after surgical revascularization. In: Circulation. 2004 ; Vol. 110, No. 12. pp. 1535-1541.
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AU - Neubauer, Stefan

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