Valproate treatment normalizes EEG functional connectivity in successfully treated idiopathic generalized epilepsy patients

B. Clemens, S. Puskás, M. Besenyei, N. Zs Kovács, T. Spisák, S. A. Kis, M. Emri, K. Hollódy, A. Fogarasi, I. Kondákor, I. Fekete

Research output: Article

14 Citations (Scopus)

Abstract

Aim: To investigate the effect of chronic VPA treatment of EEG functional connectivity in successfully treated idiopathic generalized epilepsy (IGE) patients. Patients and methods: 19-channel waking, resting-state EEG records of 26 IGE patients were analyzed before treatment (IGE) and after the 90th day of treatment (VPA), in seizure-free condition. Three minutes of artifact-free EEG background activity (without epileptiform potentials) was analyzed for each patient in both conditions. A group of 26 age-matched healthy normative control persons (NC) was analyzed in the same way. All the EEG samples were processed to LORETA (Low Resolution Electromagnetic Tomography) to localize multiple distributed sources of EEG activity. Current source density time series were generated for 33 regions of interest (ROI) in each hemisphere for four frequency bands. Pearson correlation coefficients (. R) were computed between all ROIs in each hemisphere, for four bands across the investigated samples. R values corresponded to intrahemispheric, cortico-cortical functional EEG connectivity (EEGfC). Group and condition differences were analyzed by statistical parametric network method. Main results: p

Original languageEnglish
Pages (from-to)1896-1903
Number of pages8
JournalEpilepsy Research
Volume108
Issue number10
DOIs
Publication statusPublished - dec. 1 2014

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Valproic Acid
Electroencephalography
Therapeutics
Electromagnetic Phenomena
Artifacts
Idiopathic Generalized Epilepsy
Seizures
Age Groups
Tomography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Valproate treatment normalizes EEG functional connectivity in successfully treated idiopathic generalized epilepsy patients. / Clemens, B.; Puskás, S.; Besenyei, M.; Kovács, N. Zs; Spisák, T.; Kis, S. A.; Emri, M.; Hollódy, K.; Fogarasi, A.; Kondákor, I.; Fekete, I.

In: Epilepsy Research, Vol. 108, No. 10, 01.12.2014, p. 1896-1903.

Research output: Article

Clemens, B. ; Puskás, S. ; Besenyei, M. ; Kovács, N. Zs ; Spisák, T. ; Kis, S. A. ; Emri, M. ; Hollódy, K. ; Fogarasi, A. ; Kondákor, I. ; Fekete, I. / Valproate treatment normalizes EEG functional connectivity in successfully treated idiopathic generalized epilepsy patients. In: Epilepsy Research. 2014 ; Vol. 108, No. 10. pp. 1896-1903.
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