Abstract

Rabies vaccine strain was isolated from a red fox (Vulpes vulpes)with signs of neurological disorder during an oral vaccination campaign in 2015, Hungary. The whole genome sequence of the isolated strain shared >99.9% nucleotide sequence identity to the whole genomes of vaccines strains recently used in Hungarian oral vaccination campaigns. The neuroinvasive potential of rabies vaccines that leads to development of clinical manifestations is rarely seen among wild animals; however, the observed residual pathogenicity needs awareness of field experts and requires close monitoring of rabies cases in areas where elimination programs are implemented.

Original languageEnglish
JournalVaccine
DOIs
Publication statusPublished - jan. 1 2019

Fingerprint

Rabies Vaccines
Hungary
Vulpes vulpes
rabies
oral vaccination
Immunization Programs
vaccines
Genome
Wild Animals
genome
nervous system diseases
Rabies
wild animals
Nervous System Diseases
Virulence
pathogenicity
Vaccines
nucleotide sequences
monitoring

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Vaccine-associated rabies in red fox, Hungary. / Forró, Barbara; Marton, Szilvia; Kecskeméti, S.; Hornyák, A.; Bányai, K.

In: Vaccine, 01.01.2019.

Research output: Article

@article{48920039a8994e52b9c4c5828e38c582,
title = "Vaccine-associated rabies in red fox, Hungary",
abstract = "Rabies vaccine strain was isolated from a red fox (Vulpes vulpes)with signs of neurological disorder during an oral vaccination campaign in 2015, Hungary. The whole genome sequence of the isolated strain shared >99.9{\%} nucleotide sequence identity to the whole genomes of vaccines strains recently used in Hungarian oral vaccination campaigns. The neuroinvasive potential of rabies vaccines that leads to development of clinical manifestations is rarely seen among wild animals; however, the observed residual pathogenicity needs awareness of field experts and requires close monitoring of rabies cases in areas where elimination programs are implemented.",
keywords = "Hungary, Rabies, Vaccination, Wildlife",
author = "Barbara Forr{\'o} and Szilvia Marton and S. Kecskem{\'e}ti and A. Horny{\'a}k and K. B{\'a}nyai",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.vaccine.2019.05.014",
language = "English",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Vaccine-associated rabies in red fox, Hungary

AU - Forró, Barbara

AU - Marton, Szilvia

AU - Kecskeméti, S.

AU - Hornyák, A.

AU - Bányai, K.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Rabies vaccine strain was isolated from a red fox (Vulpes vulpes)with signs of neurological disorder during an oral vaccination campaign in 2015, Hungary. The whole genome sequence of the isolated strain shared >99.9% nucleotide sequence identity to the whole genomes of vaccines strains recently used in Hungarian oral vaccination campaigns. The neuroinvasive potential of rabies vaccines that leads to development of clinical manifestations is rarely seen among wild animals; however, the observed residual pathogenicity needs awareness of field experts and requires close monitoring of rabies cases in areas where elimination programs are implemented.

AB - Rabies vaccine strain was isolated from a red fox (Vulpes vulpes)with signs of neurological disorder during an oral vaccination campaign in 2015, Hungary. The whole genome sequence of the isolated strain shared >99.9% nucleotide sequence identity to the whole genomes of vaccines strains recently used in Hungarian oral vaccination campaigns. The neuroinvasive potential of rabies vaccines that leads to development of clinical manifestations is rarely seen among wild animals; however, the observed residual pathogenicity needs awareness of field experts and requires close monitoring of rabies cases in areas where elimination programs are implemented.

KW - Hungary

KW - Rabies

KW - Vaccination

KW - Wildlife

UR - http://www.scopus.com/inward/record.url?scp=85065799593&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065799593&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2019.05.014

DO - 10.1016/j.vaccine.2019.05.014

M3 - Article

AN - SCOPUS:85065799593

JO - Vaccine

JF - Vaccine

SN - 0264-410X

ER -