Genom polimorfizmus vizsgálatok alkalmazása allogén csontvelö-transzplantációt követöen.

P. Páldi-Haris, A. Bartha, A. Bátai, S. Nahajevszky, K. Pálóczi, J. Földi

Research output: Review article

Abstract

The study of structures polymorphic in size found in the human genom (the VNTR loci) enables us to differentiate two individuals or--after bone marrow transplantation--to detect the simultaneous presence of two genoms in patients' blood or marrow. The existence of mixed chimerism may influence the therapy. The authors have screened 54 patients, transplanted in their Institute, and their donors by determination of four polymorphic loci. Informative marker was found in 43 cases. The bone marrow transplantation immunotherapy of 29 patients could be followed over 2-36 months. To increase the sensitivity of the polymerase chain reaction method used, the authors introduced the blotting/hybridization steps using isotop labeled repetitive sequences. The results are presented in comparison with literature data.

Original languageHungarian
Pages (from-to)3075-3078
Number of pages4
JournalOrvosi hetilap
Volume139
Issue number51
Publication statusPublished - dec. 20 1998

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Páldi-Haris, P., Bartha, A., Bátai, A., Nahajevszky, S., Pálóczi, K., & Földi, J. (1998). Genom polimorfizmus vizsgálatok alkalmazása allogén csontvelö-transzplantációt követöen. Orvosi hetilap, 139(51), 3075-3078.