A rare case of a patient with Sjögren's syndrome is described associated with proteinuria, microscopic hematuria, and gradually deteoriating kidney function. Renal biopsy has shown interstitial nephritis and vasculitis. The patient also had recurrent chronic genital herpes and was positive to human papilloma virus. The patient was treated with high dose corticosteroids. Due to the worsening renal function caused by the progressing vascuilits, cyclophosphamide therapy was inevitable even though the viral infection was a contraindicating factor. Therefore, along with antiviral therapy (acyclovir), we initiated cyclophosphamide therapy whereby the patient's kidney functions improved without progression of the infection. In patients with Sjögren's syndrome the deterioration of the renal function may raise the possibility of ongoing renal vasculitis, therefore thorough nephrological investigations are necessary and if the diagnosis is proven adequate immunosuppressive therapy needs to be initiated immediately, despite the risk of activating any associated infectious diseases.
|Title of host publication||Autoimmune Disorders|
|Subtitle of host publication||Symptoms, Diagnosis and Treatment|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||6|
|Publication status||Published - jan. 1 2011|
ASJC Scopus subject areas