Underexpression of C-myc in adrenocortical cancer: A major pathogenic event?

P. M. Szabó, K. Rácz, P. Igaz

Research output: Review article

10 Citations (Scopus)


The protooncogene c-myc is a major factor in tumourigenesis. Whereas c-myc overexpression is considered to be a general feature of many tumours, we have recently demonstrated c-myc underexpression in adrenocortical cancer by a meta-analysis. We hypothesise that c-myc underexpression might be a central event in adrenortical tumourigenesis based on network topology modelling and previous experimental observations. In this brief hypothesis, we present our arguments and their possible relevance.

Original languageEnglish
Pages (from-to)297-299
Number of pages3
JournalHormone and Metabolic Research
Issue number5
Publication statusPublished - márc. 17 2011

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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