Ubiquitin sets the timer: Impacts on aging and longevity

Éva Kevei, Thorsten Hoppe

Research output: Review article

31 Citations (Scopus)

Abstract

Protein homeostasis is essential for cellular function, organismal growth and viability. Damaged and aggregated proteins are turned over by two major proteolytic routes of the cellular quality-control pathways: the ubiquitin-proteasome system and autophagy. For both these pathways, ubiquitination provides the recognition signal for substrate selection. This Commentary discusses how ubiquitin-dependent proteolytic pathways are coordinated with stress- and aging-induced signals.

Original languageEnglish
Pages (from-to)290-292
Number of pages3
JournalNature Structural and Molecular Biology
Volume21
Issue number4
DOIs
Publication statusPublished - ápr. 2014

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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