A tumormozgások jelentoségének sokszeletes-CT- alapú képfúziós vizsgálata tüdodaganatos betegek sugárkezelésénél

Árpád Kovács, Janaki Hadjiev, Ferenc Lakosi, Gergely Antal, Ákos Horváth, P. Bogner, I. Repa

Research output: Article

Abstract

The aim of our study was to detect the possible uncertainties arising from tumor movements in the daily routine treatment planning, in extreme breathing conditions. Ten patients with lung cancer were enrolled into the study. According to tumor location, five patients had periferial and five had central tumor. After the normal planning CT scan, two more scans were made with the same CT parameters in maximal exhalation and in maximal inhalation. For planning, the normal breathing scans were used with the fusion of the maximal inhalation and maximal exhalation scans. After the fusion in all breathing phases the gross tumor volumes were contoured (GTV1, GTV2, GTV3). Around the GTV1 (normal breathing phase GTV) 3 planning target volumes (PTV) were generated with the margin of 0.5 cm, 1.5 cm and 2.5 cm (PTV1, PTV2, PTV3). Individual plans were generated to all PTVs. All GTV volumes were registered. In all cases volume deviations were registered in different breathing phases (min: 1.5%, max: 35.6%). For GTV coverage comparison the coverage index (CI) was used. In case of extreme breathing conditions, using 0.5 cm margin was sufficient to reach good coverage for central tumors. For periferal tumors 1.5 cm margin had to be used for the acceptable coverage (CI: 0.85-1.00). In our study, extreme breathing conditions were analyzed. According to our results, CT scans used in the daily routine do not exactly represent the tumor midposition and the true tumor volume. Due to breathing synchron tumor movements, 0.5 cm margin must be used for planning in central location. In periferal tumors wider margin should be used.

Original languageHungarian
Pages (from-to)219-223
Number of pages5
JournalMagyar Onkologia
Volume51
Issue number3
Publication statusPublished - 2007

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Lung Neoplasms
Respiration
Radiotherapy
Neoplasms
Exhalation
Tumor Burden
Inhalation
Uncertainty

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

A tumormozgások jelentoségének sokszeletes-CT- alapú képfúziós vizsgálata tüdodaganatos betegek sugárkezelésénél. / Kovács, Árpád; Hadjiev, Janaki; Lakosi, Ferenc; Antal, Gergely; Horváth, Ákos; Bogner, P.; Repa, I.

In: Magyar Onkologia, Vol. 51, No. 3, 2007, p. 219-223.

Research output: Article

Kovács, Árpád ; Hadjiev, Janaki ; Lakosi, Ferenc ; Antal, Gergely ; Horváth, Ákos ; Bogner, P. ; Repa, I. / A tumormozgások jelentoségének sokszeletes-CT- alapú képfúziós vizsgálata tüdodaganatos betegek sugárkezelésénél. In: Magyar Onkologia. 2007 ; Vol. 51, No. 3. pp. 219-223.
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abstract = "The aim of our study was to detect the possible uncertainties arising from tumor movements in the daily routine treatment planning, in extreme breathing conditions. Ten patients with lung cancer were enrolled into the study. According to tumor location, five patients had periferial and five had central tumor. After the normal planning CT scan, two more scans were made with the same CT parameters in maximal exhalation and in maximal inhalation. For planning, the normal breathing scans were used with the fusion of the maximal inhalation and maximal exhalation scans. After the fusion in all breathing phases the gross tumor volumes were contoured (GTV1, GTV2, GTV3). Around the GTV1 (normal breathing phase GTV) 3 planning target volumes (PTV) were generated with the margin of 0.5 cm, 1.5 cm and 2.5 cm (PTV1, PTV2, PTV3). Individual plans were generated to all PTVs. All GTV volumes were registered. In all cases volume deviations were registered in different breathing phases (min: 1.5{\%}, max: 35.6{\%}). For GTV coverage comparison the coverage index (CI) was used. In case of extreme breathing conditions, using 0.5 cm margin was sufficient to reach good coverage for central tumors. For periferal tumors 1.5 cm margin had to be used for the acceptable coverage (CI: 0.85-1.00). In our study, extreme breathing conditions were analyzed. According to our results, CT scans used in the daily routine do not exactly represent the tumor midposition and the true tumor volume. Due to breathing synchron tumor movements, 0.5 cm margin must be used for planning in central location. In periferal tumors wider margin should be used.",
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AU - Hadjiev, Janaki

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AU - Horváth, Ákos

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AU - Repa, I.

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