Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic stroke

L. Járomi, V. Csöngei, Noémi Polgár, Gábor Rappai, Z. Szolnoki, A. Maász, Katalin Horvatovich, E. Sáfrány, C. Sipeky, L. Magyari, B. Melegh

Research output: Article

4 Citations (Scopus)

Abstract

Stroke is a common multifactorial disease, and the third leading cause of death worldwide, which results in serious long-term mental and physical disability among survivors. The role of affected triglyceride metabolism in the development of ischemic stroke is under extensive investigations. Here, we examined three SNPs, rs12130333 located within the ANGPTL3 locus; rs16996148 residing at the CILP2 gene locus; and rs17321515 at the TRIB1 locus, which were originally reported in association with decreased triglyceride levels; therefore, we investigated their possible protective effect against the development of ischemic stroke. A total of 459 Caucasian stroke patients, stratified as large-vessel, small-vessel, and mixed stroke groups, and 168 control subjects were genotyped using PCR-RFLP methods. As a result, we could not detect any differences in triglyceride or total cholesterol levels in relation to any allelic variants of rs16996148, rs17321515, or rs12130333 SNPs. No correlation was found between the minor alleles rs16996148-T (P = 0.881), rs17321515-G (P = 0.070), or rs12130333-T allele (P = 0.757) and the risk for development of stroke. The data presented here suggest different scale of effect of triglyceride modifier alleles and also their variable susceptibility or protective nature.

Original languageEnglish
Pages (from-to)179-186
Number of pages8
JournalNeuroMolecular Medicine
Volume13
Issue number3
DOIs
Publication statusPublished - szept. 2011

Fingerprint

Triglycerides
Stroke
Alleles
Single Nucleotide Polymorphism
Restriction Fragment Length Polymorphisms
Survivors
Cause of Death
Cholesterol
Polymerase Chain Reaction
Control Groups
Genes

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Molecular Medicine
  • Neurology

Cite this

@article{270fc6efbc4344339a3ac3dc50ef9ce8,
title = "Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic stroke",
abstract = "Stroke is a common multifactorial disease, and the third leading cause of death worldwide, which results in serious long-term mental and physical disability among survivors. The role of affected triglyceride metabolism in the development of ischemic stroke is under extensive investigations. Here, we examined three SNPs, rs12130333 located within the ANGPTL3 locus; rs16996148 residing at the CILP2 gene locus; and rs17321515 at the TRIB1 locus, which were originally reported in association with decreased triglyceride levels; therefore, we investigated their possible protective effect against the development of ischemic stroke. A total of 459 Caucasian stroke patients, stratified as large-vessel, small-vessel, and mixed stroke groups, and 168 control subjects were genotyped using PCR-RFLP methods. As a result, we could not detect any differences in triglyceride or total cholesterol levels in relation to any allelic variants of rs16996148, rs17321515, or rs12130333 SNPs. No correlation was found between the minor alleles rs16996148-T (P = 0.881), rs17321515-G (P = 0.070), or rs12130333-T allele (P = 0.757) and the risk for development of stroke. The data presented here suggest different scale of effect of triglyceride modifier alleles and also their variable susceptibility or protective nature.",
keywords = "ANGPTL3, Cholesterol, CILP2, Stroke, TRIB1, Triglyceride",
author = "L. J{\'a}romi and V. Cs{\"o}ngei and No{\'e}mi Polg{\'a}r and G{\'a}bor Rappai and Z. Szolnoki and A. Ma{\'a}sz and Katalin Horvatovich and E. S{\'a}fr{\'a}ny and C. Sipeky and L. Magyari and B. Melegh",
year = "2011",
month = "9",
doi = "10.1007/s12017-011-8149-7",
language = "English",
volume = "13",
pages = "179--186",
journal = "NeuroMolecular Medicine",
issn = "1535-1084",
publisher = "Humana Press",
number = "3",

}

TY - JOUR

T1 - Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic stroke

AU - Járomi, L.

AU - Csöngei, V.

AU - Polgár, Noémi

AU - Rappai, Gábor

AU - Szolnoki, Z.

AU - Maász, A.

AU - Horvatovich, Katalin

AU - Sáfrány, E.

AU - Sipeky, C.

AU - Magyari, L.

AU - Melegh, B.

PY - 2011/9

Y1 - 2011/9

N2 - Stroke is a common multifactorial disease, and the third leading cause of death worldwide, which results in serious long-term mental and physical disability among survivors. The role of affected triglyceride metabolism in the development of ischemic stroke is under extensive investigations. Here, we examined three SNPs, rs12130333 located within the ANGPTL3 locus; rs16996148 residing at the CILP2 gene locus; and rs17321515 at the TRIB1 locus, which were originally reported in association with decreased triglyceride levels; therefore, we investigated their possible protective effect against the development of ischemic stroke. A total of 459 Caucasian stroke patients, stratified as large-vessel, small-vessel, and mixed stroke groups, and 168 control subjects were genotyped using PCR-RFLP methods. As a result, we could not detect any differences in triglyceride or total cholesterol levels in relation to any allelic variants of rs16996148, rs17321515, or rs12130333 SNPs. No correlation was found between the minor alleles rs16996148-T (P = 0.881), rs17321515-G (P = 0.070), or rs12130333-T allele (P = 0.757) and the risk for development of stroke. The data presented here suggest different scale of effect of triglyceride modifier alleles and also their variable susceptibility or protective nature.

AB - Stroke is a common multifactorial disease, and the third leading cause of death worldwide, which results in serious long-term mental and physical disability among survivors. The role of affected triglyceride metabolism in the development of ischemic stroke is under extensive investigations. Here, we examined three SNPs, rs12130333 located within the ANGPTL3 locus; rs16996148 residing at the CILP2 gene locus; and rs17321515 at the TRIB1 locus, which were originally reported in association with decreased triglyceride levels; therefore, we investigated their possible protective effect against the development of ischemic stroke. A total of 459 Caucasian stroke patients, stratified as large-vessel, small-vessel, and mixed stroke groups, and 168 control subjects were genotyped using PCR-RFLP methods. As a result, we could not detect any differences in triglyceride or total cholesterol levels in relation to any allelic variants of rs16996148, rs17321515, or rs12130333 SNPs. No correlation was found between the minor alleles rs16996148-T (P = 0.881), rs17321515-G (P = 0.070), or rs12130333-T allele (P = 0.757) and the risk for development of stroke. The data presented here suggest different scale of effect of triglyceride modifier alleles and also their variable susceptibility or protective nature.

KW - ANGPTL3

KW - Cholesterol

KW - CILP2

KW - Stroke

KW - TRIB1

KW - Triglyceride

UR - http://www.scopus.com/inward/record.url?scp=84855897716&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855897716&partnerID=8YFLogxK

U2 - 10.1007/s12017-011-8149-7

DO - 10.1007/s12017-011-8149-7

M3 - Article

VL - 13

SP - 179

EP - 186

JO - NeuroMolecular Medicine

JF - NeuroMolecular Medicine

SN - 1535-1084

IS - 3

ER -