Abstract
Stroke is a common multifactorial disease, and the third leading cause of death worldwide, which results in serious long-term mental and physical disability among survivors. The role of affected triglyceride metabolism in the development of ischemic stroke is under extensive investigations. Here, we examined three SNPs, rs12130333 located within the ANGPTL3 locus; rs16996148 residing at the CILP2 gene locus; and rs17321515 at the TRIB1 locus, which were originally reported in association with decreased triglyceride levels; therefore, we investigated their possible protective effect against the development of ischemic stroke. A total of 459 Caucasian stroke patients, stratified as large-vessel, small-vessel, and mixed stroke groups, and 168 control subjects were genotyped using PCR-RFLP methods. As a result, we could not detect any differences in triglyceride or total cholesterol levels in relation to any allelic variants of rs16996148, rs17321515, or rs12130333 SNPs. No correlation was found between the minor alleles rs16996148-T (P = 0.881), rs17321515-G (P = 0.070), or rs12130333-T allele (P = 0.757) and the risk for development of stroke. The data presented here suggest different scale of effect of triglyceride modifier alleles and also their variable susceptibility or protective nature.
| Original language | English |
|---|---|
| Pages (from-to) | 179-186 |
| Number of pages | 8 |
| Journal | NeuroMolecular Medicine |
| Volume | 13 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - szept. 2011 |
Fingerprint
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Molecular Medicine
- Neurology
Cite this
Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic stroke. / Járomi, L.; Csöngei, V.; Polgár, Noémi; Rappai, Gábor; Szolnoki, Z.; Maász, A.; Horvatovich, Katalin; Sáfrány, E.; Sipeky, C.; Magyari, L.; Melegh, B.
In: NeuroMolecular Medicine, Vol. 13, No. 3, 09.2011, p. 179-186.Research output: Article
}
TY - JOUR
T1 - Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic stroke
AU - Járomi, L.
AU - Csöngei, V.
AU - Polgár, Noémi
AU - Rappai, Gábor
AU - Szolnoki, Z.
AU - Maász, A.
AU - Horvatovich, Katalin
AU - Sáfrány, E.
AU - Sipeky, C.
AU - Magyari, L.
AU - Melegh, B.
PY - 2011/9
Y1 - 2011/9
N2 - Stroke is a common multifactorial disease, and the third leading cause of death worldwide, which results in serious long-term mental and physical disability among survivors. The role of affected triglyceride metabolism in the development of ischemic stroke is under extensive investigations. Here, we examined three SNPs, rs12130333 located within the ANGPTL3 locus; rs16996148 residing at the CILP2 gene locus; and rs17321515 at the TRIB1 locus, which were originally reported in association with decreased triglyceride levels; therefore, we investigated their possible protective effect against the development of ischemic stroke. A total of 459 Caucasian stroke patients, stratified as large-vessel, small-vessel, and mixed stroke groups, and 168 control subjects were genotyped using PCR-RFLP methods. As a result, we could not detect any differences in triglyceride or total cholesterol levels in relation to any allelic variants of rs16996148, rs17321515, or rs12130333 SNPs. No correlation was found between the minor alleles rs16996148-T (P = 0.881), rs17321515-G (P = 0.070), or rs12130333-T allele (P = 0.757) and the risk for development of stroke. The data presented here suggest different scale of effect of triglyceride modifier alleles and also their variable susceptibility or protective nature.
AB - Stroke is a common multifactorial disease, and the third leading cause of death worldwide, which results in serious long-term mental and physical disability among survivors. The role of affected triglyceride metabolism in the development of ischemic stroke is under extensive investigations. Here, we examined three SNPs, rs12130333 located within the ANGPTL3 locus; rs16996148 residing at the CILP2 gene locus; and rs17321515 at the TRIB1 locus, which were originally reported in association with decreased triglyceride levels; therefore, we investigated their possible protective effect against the development of ischemic stroke. A total of 459 Caucasian stroke patients, stratified as large-vessel, small-vessel, and mixed stroke groups, and 168 control subjects were genotyped using PCR-RFLP methods. As a result, we could not detect any differences in triglyceride or total cholesterol levels in relation to any allelic variants of rs16996148, rs17321515, or rs12130333 SNPs. No correlation was found between the minor alleles rs16996148-T (P = 0.881), rs17321515-G (P = 0.070), or rs12130333-T allele (P = 0.757) and the risk for development of stroke. The data presented here suggest different scale of effect of triglyceride modifier alleles and also their variable susceptibility or protective nature.
KW - ANGPTL3
KW - Cholesterol
KW - CILP2
KW - Stroke
KW - TRIB1
KW - Triglyceride
UR - http://www.scopus.com/inward/record.url?scp=84855897716&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855897716&partnerID=8YFLogxK
U2 - 10.1007/s12017-011-8149-7
DO - 10.1007/s12017-011-8149-7
M3 - Article
VL - 13
SP - 179
EP - 186
JO - NeuroMolecular Medicine
JF - NeuroMolecular Medicine
SN - 1535-1084
IS - 3
ER -