Treatment of type i and II hereditary angioedema with Rhucin ®, a recombinant human C1 inhibitor

Research output: Review article

9 Citations (Scopus)


Hereditary and acquired angioedema are of outstanding clinical importance, as edematous attacks associated with these conditions can thrust afflicted patients into mortal danger. Currently, C1 inhibitor concentrate - a human blood product - is available as a replacement therapy. In view of the limited number of donors, as well as the risk of transmission of blood-borne infections, it is a reasonable expectation to develop a therapeutic alternative based on recombinant technology, which would eliminate all these shortcomings. Pharming (Leiden, The Netherlands) has developed Rhucin®, a recombinant human C1 inhibitor, as a proprietary product, which is currently being evaluated in Phase III clinical trials. Ongoing studies conducted within the framework of the development program are almost complete and their interim findings are reassuring. This should facilitate successful regulatory approval in the near future, which is indispensable in order to make Rhucin available for patients with hereditary angioedema or other disorders amenable to C1 inhibitor replacement.

Original languageEnglish
Pages (from-to)653-661
Number of pages9
JournalExpert review of clinical immunology
Issue number6
Publication statusPublished - dec. 1 2008


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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