Treatment of pituitary tumors: Dopamine agonists

Gabriella Iván, Nikoletta Szigeti-Csúcs, Márk Oláh, György M. Nagy, Miklós I. Góth

Research output: Review article

42 Citations (Scopus)

Abstract

The neurotransmitter/neuromodulator dopamine plays an important role in both the central nervous system and the periphery. In the hypothalamopituitary system its function is a dominant and tonic inhibitory regulation of pituitary hormone secretion including prolactin- and proopiomelanocortin-derived hormones. It is well known that dopamine agonists, such as bromocriptine, pergolide, quinagolide, cabergoline, and lisuride, can inhibit PRL secretion by binding to the D2 dopamine receptors located on normal as well as tumorous pituitary cells. Moreover, they can effectively decrease excessive PRL secretion as well as the size of the tumor in patients having prolactinoma. Furthermore, dopamine agonists can also be used in other pituitary tumors. The major requirement for its use is that the tumor cells should express D2 receptors. Therefore, in addition to prolactinomas, targets of dopamine agonist therapy are somatotroph tumors, nonfunctioning pituitary tumors, corticotroph pituitary tumors, Nelson's syndrome, gonadotropinomas, and thyrotropin-secreting pituitary tumors. It is also an option for the treatment of pituitary disease during pregnancy. Differences between the effectiveness and the resistance of different dopaminergic agents as well as the future perspectives of them in the therapy of pituitary tumors are discussed.

Original languageEnglish
Pages (from-to)101-110
Number of pages10
JournalEndocrine
Volume28
Issue number1
DOIs
Publication statusPublished - okt. 2005

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Treatment of pituitary tumors: Dopamine agonists'. Together they form a unique fingerprint.

  • Cite this

    Iván, G., Szigeti-Csúcs, N., Oláh, M., Nagy, G. M., & Góth, M. I. (2005). Treatment of pituitary tumors: Dopamine agonists. Endocrine, 28(1), 101-110. https://doi.org/10.1385/endo:28:1:101