Abstract
The main problems which occur during the preparation of solid dosage forms (especially tablets and capsules) are the insufficient flow of the particles, poor compactibility and inadequate stability of the materials. The aim of preformulation, therefore, is to eliminate such problems, if possible. The effects of granulation and coating were examined. Dimenhydrinate was chosen as a model drug with low-flow properties and decomposition at the melting point. The shape of the particles and the flow properties (angle of repose, mass by volume, flow time, the Hausner factor and Carr's index) were determined. Differential scanning calorimetry was used to check the features of the sample on exposure to heat and to measure the melting point. The effect of the coating film on the melting point was observed during melting.
| Original language | English |
|---|---|
| Pages (from-to) | 25-29 |
| Number of pages | 5 |
| Journal | Drugs Made in Germany |
| Volume | 45 |
| Issue number | 1 |
| Publication status | Published - 2002 |
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ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology (medical)
- Pharmacology
Cite this
Treatment of particles with low-flow properties. / Bajdik, János; Pintye-Hódi, K.; Regdon, Géza; Erös, I.
In: Drugs Made in Germany, Vol. 45, No. 1, 2002, p. 25-29.Research output: Article
}
TY - JOUR
T1 - Treatment of particles with low-flow properties
AU - Bajdik, János
AU - Pintye-Hódi, K.
AU - Regdon, Géza
AU - Erös, I.
PY - 2002
Y1 - 2002
N2 - The main problems which occur during the preparation of solid dosage forms (especially tablets and capsules) are the insufficient flow of the particles, poor compactibility and inadequate stability of the materials. The aim of preformulation, therefore, is to eliminate such problems, if possible. The effects of granulation and coating were examined. Dimenhydrinate was chosen as a model drug with low-flow properties and decomposition at the melting point. The shape of the particles and the flow properties (angle of repose, mass by volume, flow time, the Hausner factor and Carr's index) were determined. Differential scanning calorimetry was used to check the features of the sample on exposure to heat and to measure the melting point. The effect of the coating film on the melting point was observed during melting.
AB - The main problems which occur during the preparation of solid dosage forms (especially tablets and capsules) are the insufficient flow of the particles, poor compactibility and inadequate stability of the materials. The aim of preformulation, therefore, is to eliminate such problems, if possible. The effects of granulation and coating were examined. Dimenhydrinate was chosen as a model drug with low-flow properties and decomposition at the melting point. The shape of the particles and the flow properties (angle of repose, mass by volume, flow time, the Hausner factor and Carr's index) were determined. Differential scanning calorimetry was used to check the features of the sample on exposure to heat and to measure the melting point. The effect of the coating film on the melting point was observed during melting.
KW - Differential scanning calorimetry
KW - Dimenhydrinate
KW - Film coating
KW - Hydroxypropylcellulose
KW - Particles, agglomeration, flow properties
KW - Solid dosage forms
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UR - http://www.scopus.com/inward/citedby.url?scp=0036210699&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0036210699
VL - 45
SP - 25
EP - 29
JO - Drugs Made in Germany
JF - Drugs Made in Germany
SN - 0012-6683
IS - 1
ER -