Tracking the physical aging of poly(ethylene oxide): A technical note

Dorottya Kiss, K. Süvegh, T. Marek, Laszlo Dévényi, C. Novák, R. Zelkó

Research output: Article

10 Citations (Scopus)

Abstract

Physical aging of 2 types of PEO could be tracked by the combination of PALS, DSC, and SEM methods. After storing the samples a 40°C ± 2°C and 75% ± 5% RH, a decrease in the o-Ps lifetime values and an increase in the melting enthalpies as a function of storage time indicated a reorientation of the polymer chains. The limitations of monitoring enthalpy relaxation confirm the importance of methods that track volume relaxation, such as PALS. Structural changes could be observed even after a short storage time (4 weeks), which highlights the effect of further investigations of the influence of physical aging on the properties of PEO-containing dosage forms.

Original languageEnglish
Article number95
JournalAAPS PharmSciTech
Volume7
Issue number4
Publication statusPublished - dec. 15 2006

Fingerprint

Ethylene Oxide
enthalpy
polyethylene glycol
storage time
Dosage Forms
melting
Freezing
polymers
Polymers
monitoring
dosage
methodology
sampling

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

Cite this

Tracking the physical aging of poly(ethylene oxide) : A technical note. / Kiss, Dorottya; Süvegh, K.; Marek, T.; Dévényi, Laszlo; Novák, C.; Zelkó, R.

In: AAPS PharmSciTech, Vol. 7, No. 4, 95, 15.12.2006.

Research output: Article

@article{388e1d056f694625b97ca99dedbb98de,
title = "Tracking the physical aging of poly(ethylene oxide): A technical note",
abstract = "Physical aging of 2 types of PEO could be tracked by the combination of PALS, DSC, and SEM methods. After storing the samples a 40°C ± 2°C and 75{\%} ± 5{\%} RH, a decrease in the o-Ps lifetime values and an increase in the melting enthalpies as a function of storage time indicated a reorientation of the polymer chains. The limitations of monitoring enthalpy relaxation confirm the importance of methods that track volume relaxation, such as PALS. Structural changes could be observed even after a short storage time (4 weeks), which highlights the effect of further investigations of the influence of physical aging on the properties of PEO-containing dosage forms.",
keywords = "Amorphous, Differential scanning calorimetry, Physical aging, Poly(ethylene oxide), Positron annihilation lifetime spectroscopy",
author = "Dorottya Kiss and K. S{\"u}vegh and T. Marek and Laszlo D{\'e}v{\'e}nyi and C. Nov{\'a}k and R. Zelk{\'o}",
year = "2006",
month = "12",
day = "15",
language = "English",
volume = "7",
journal = "AAPS PharmSciTech",
issn = "1530-9932",
publisher = "American Association of Pharmaceutical Scientists",
number = "4",

}

TY - JOUR

T1 - Tracking the physical aging of poly(ethylene oxide)

T2 - A technical note

AU - Kiss, Dorottya

AU - Süvegh, K.

AU - Marek, T.

AU - Dévényi, Laszlo

AU - Novák, C.

AU - Zelkó, R.

PY - 2006/12/15

Y1 - 2006/12/15

N2 - Physical aging of 2 types of PEO could be tracked by the combination of PALS, DSC, and SEM methods. After storing the samples a 40°C ± 2°C and 75% ± 5% RH, a decrease in the o-Ps lifetime values and an increase in the melting enthalpies as a function of storage time indicated a reorientation of the polymer chains. The limitations of monitoring enthalpy relaxation confirm the importance of methods that track volume relaxation, such as PALS. Structural changes could be observed even after a short storage time (4 weeks), which highlights the effect of further investigations of the influence of physical aging on the properties of PEO-containing dosage forms.

AB - Physical aging of 2 types of PEO could be tracked by the combination of PALS, DSC, and SEM methods. After storing the samples a 40°C ± 2°C and 75% ± 5% RH, a decrease in the o-Ps lifetime values and an increase in the melting enthalpies as a function of storage time indicated a reorientation of the polymer chains. The limitations of monitoring enthalpy relaxation confirm the importance of methods that track volume relaxation, such as PALS. Structural changes could be observed even after a short storage time (4 weeks), which highlights the effect of further investigations of the influence of physical aging on the properties of PEO-containing dosage forms.

KW - Amorphous

KW - Differential scanning calorimetry

KW - Physical aging

KW - Poly(ethylene oxide)

KW - Positron annihilation lifetime spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=33846097608&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846097608&partnerID=8YFLogxK

M3 - Article

C2 - 17285751

AN - SCOPUS:33846097608

VL - 7

JO - AAPS PharmSciTech

JF - AAPS PharmSciTech

SN - 1530-9932

IS - 4

M1 - 95

ER -