Tracking of airway and tissue mechanics during TLC maneuvers in mice

Z. Hantos, Rachel A. Collins, Debra J. Turner, Tibor Z. Jánosi, Peter D. Sly

Research output: Article

47 Citations (Scopus)

Abstract

A tracking impedance estimation technique was developed to follow the changes in total respiratory impedance (Zrs) during slow total lung capacity maneuvers in six anesthetized and mechanically ventilated BALB/c mice. Zrs was measured with the wave-tube technique and pseudorandom forced oscillations at nine frequencies between 4 and 38 Hz during inflation from a transrespiratory pressure of 0-20 cmH2O and subsequent deflation, each lasting for ∼20 s. Zrs was averaged for 0.125 s and fitted by a model featuring airway resistance (Raw) and inertance, and tissue damping and elastance (H). Lower airway conductance (Glaw) was linearly related to volume above functional residual capacity (V) between 0 and 75-95% maximum V, with a mean slope of dGlaw/dV = 13.6 ± 4.6 cmH2O-1·s -1. The interdependence of Raw and H was characterized by two distinct and closely linear relationships for the low- and high-volume regions, separated at ∼40% maximum V. Comparison of Raw with the highest-frequency resistance of the total respiratory system revealed a marked volume-dependent contribution of tissue resistance to total respiratory system resistance, resulting in the overestimation of Raw by 19 ± 8 and 163 ± 40% at functional residual capacity and total lung capacity, respectively, whereas the lowest frequency reactance was proportional to H; these findings indicate that single-frequency resistance values may become inappropriate as surrogates of Raw when tissue impedance is changing.

Original languageEnglish
Pages (from-to)1695-1705
Number of pages11
JournalJournal of Applied Physiology
Volume95
Issue number4
Publication statusPublished - okt. 1 2003

Fingerprint

Mechanics
Electric Impedance
Total Lung Capacity
Functional Residual Capacity
Respiratory System
Airway Resistance
Economic Inflation
Pressure

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Hantos, Z., Collins, R. A., Turner, D. J., Jánosi, T. Z., & Sly, P. D. (2003). Tracking of airway and tissue mechanics during TLC maneuvers in mice. Journal of Applied Physiology, 95(4), 1695-1705.

Tracking of airway and tissue mechanics during TLC maneuvers in mice. / Hantos, Z.; Collins, Rachel A.; Turner, Debra J.; Jánosi, Tibor Z.; Sly, Peter D.

In: Journal of Applied Physiology, Vol. 95, No. 4, 01.10.2003, p. 1695-1705.

Research output: Article

Hantos, Z, Collins, RA, Turner, DJ, Jánosi, TZ & Sly, PD 2003, 'Tracking of airway and tissue mechanics during TLC maneuvers in mice', Journal of Applied Physiology, vol. 95, no. 4, pp. 1695-1705.
Hantos Z, Collins RA, Turner DJ, Jánosi TZ, Sly PD. Tracking of airway and tissue mechanics during TLC maneuvers in mice. Journal of Applied Physiology. 2003 okt. 1;95(4):1695-1705.
Hantos, Z. ; Collins, Rachel A. ; Turner, Debra J. ; Jánosi, Tibor Z. ; Sly, Peter D. / Tracking of airway and tissue mechanics during TLC maneuvers in mice. In: Journal of Applied Physiology. 2003 ; Vol. 95, No. 4. pp. 1695-1705.
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