Toxicity of abiotic stressors to Fusarium species: Differences in hydrogen peroxide and fungicide tolerance

Emese D. Nagygyörgy, Barbara Kovács, E. Leiter, Márton Miskei, I. Pócsi, L. Hornok, A. Ádám

Research output: Article

1 Citation (Scopus)

Abstract

Stress sensitivity of three related phytopathogenic Fusarium species (Fusarium graminearum, Fusarium oxysporum and Fusarium verticillioides) to different oxidative, osmotic, cell wall, membrane, fungicide stressors and an antifungal protein (PAF) were studied in vitro. The most prominent and significant differences were found in oxidative stress tolerance: all the three F. graminearum strains showed much higher sensitivity to hydrogen peroxide and, to a lesser extent, to menadione than the other two species. High sensitivity of F. verticillioides strains was also detectable to an azole drug, Ketoconazole. Surprisingly, no or limited differences were observed in response to other oxidative, osmotic and cell wall stressors. These results indicate that fungal oxidative stress response and especially the response to hydrogen peroxide (this compound is involved in a wide range of plant-fungus interactions) might be modified on niche-specific manner in these phylogenetically related Fusarium species depending on their pathogenic strategy. Supporting the increased hydrogen peroxide sensitivity of F. graminearum, genome-wide analysis of stress signal transduction pathways revealed the absence one CatC-type catalase gene in F. graminearum in comparison to the other two species.

Original languageEnglish
Pages (from-to)189-208
Number of pages20
JournalActa Microbiologica et Immunologica Hungarica
Volume61
Issue number2
DOIs
Publication statusPublished - jún. 1 2014

Fingerprint

Fusarium
Hydrogen Peroxide
Cell Wall
Oxidative Stress
Vitamin K 3
Azoles
Ketoconazole
Catalase
Signal Transduction
Fungi
Cell Membrane
Genome
Pharmaceutical Preparations
Genes
Proteins

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

@article{7927cb9503aa473b927115ec1f3179c1,
title = "Toxicity of abiotic stressors to Fusarium species: Differences in hydrogen peroxide and fungicide tolerance",
abstract = "Stress sensitivity of three related phytopathogenic Fusarium species (Fusarium graminearum, Fusarium oxysporum and Fusarium verticillioides) to different oxidative, osmotic, cell wall, membrane, fungicide stressors and an antifungal protein (PAF) were studied in vitro. The most prominent and significant differences were found in oxidative stress tolerance: all the three F. graminearum strains showed much higher sensitivity to hydrogen peroxide and, to a lesser extent, to menadione than the other two species. High sensitivity of F. verticillioides strains was also detectable to an azole drug, Ketoconazole. Surprisingly, no or limited differences were observed in response to other oxidative, osmotic and cell wall stressors. These results indicate that fungal oxidative stress response and especially the response to hydrogen peroxide (this compound is involved in a wide range of plant-fungus interactions) might be modified on niche-specific manner in these phylogenetically related Fusarium species depending on their pathogenic strategy. Supporting the increased hydrogen peroxide sensitivity of F. graminearum, genome-wide analysis of stress signal transduction pathways revealed the absence one CatC-type catalase gene in F. graminearum in comparison to the other two species.",
keywords = "abiotic stress tolerance, catalase, Fusarium, hydrogen peroxide, Ketoconazole, niche-specific adaptation, oxidative stress",
author = "Nagygy{\"o}rgy, {Emese D.} and Barbara Kov{\'a}cs and E. Leiter and M{\'a}rton Miskei and I. P{\'o}csi and L. Hornok and A. {\'A}d{\'a}m",
year = "2014",
month = "6",
day = "1",
doi = "10.1556/AMicr.61.2014.2.9",
language = "English",
volume = "61",
pages = "189--208",
journal = "Acta Microbiologica et Immunologica Hungarica",
issn = "1217-8950",
publisher = "Akademiai Kiado",
number = "2",

}

TY - JOUR

T1 - Toxicity of abiotic stressors to Fusarium species

T2 - Differences in hydrogen peroxide and fungicide tolerance

AU - Nagygyörgy, Emese D.

AU - Kovács, Barbara

AU - Leiter, E.

AU - Miskei, Márton

AU - Pócsi, I.

AU - Hornok, L.

AU - Ádám, A.

PY - 2014/6/1

Y1 - 2014/6/1

N2 - Stress sensitivity of three related phytopathogenic Fusarium species (Fusarium graminearum, Fusarium oxysporum and Fusarium verticillioides) to different oxidative, osmotic, cell wall, membrane, fungicide stressors and an antifungal protein (PAF) were studied in vitro. The most prominent and significant differences were found in oxidative stress tolerance: all the three F. graminearum strains showed much higher sensitivity to hydrogen peroxide and, to a lesser extent, to menadione than the other two species. High sensitivity of F. verticillioides strains was also detectable to an azole drug, Ketoconazole. Surprisingly, no or limited differences were observed in response to other oxidative, osmotic and cell wall stressors. These results indicate that fungal oxidative stress response and especially the response to hydrogen peroxide (this compound is involved in a wide range of plant-fungus interactions) might be modified on niche-specific manner in these phylogenetically related Fusarium species depending on their pathogenic strategy. Supporting the increased hydrogen peroxide sensitivity of F. graminearum, genome-wide analysis of stress signal transduction pathways revealed the absence one CatC-type catalase gene in F. graminearum in comparison to the other two species.

AB - Stress sensitivity of three related phytopathogenic Fusarium species (Fusarium graminearum, Fusarium oxysporum and Fusarium verticillioides) to different oxidative, osmotic, cell wall, membrane, fungicide stressors and an antifungal protein (PAF) were studied in vitro. The most prominent and significant differences were found in oxidative stress tolerance: all the three F. graminearum strains showed much higher sensitivity to hydrogen peroxide and, to a lesser extent, to menadione than the other two species. High sensitivity of F. verticillioides strains was also detectable to an azole drug, Ketoconazole. Surprisingly, no or limited differences were observed in response to other oxidative, osmotic and cell wall stressors. These results indicate that fungal oxidative stress response and especially the response to hydrogen peroxide (this compound is involved in a wide range of plant-fungus interactions) might be modified on niche-specific manner in these phylogenetically related Fusarium species depending on their pathogenic strategy. Supporting the increased hydrogen peroxide sensitivity of F. graminearum, genome-wide analysis of stress signal transduction pathways revealed the absence one CatC-type catalase gene in F. graminearum in comparison to the other two species.

KW - abiotic stress tolerance

KW - catalase

KW - Fusarium

KW - hydrogen peroxide

KW - Ketoconazole

KW - niche-specific adaptation

KW - oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=84902794250&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902794250&partnerID=8YFLogxK

U2 - 10.1556/AMicr.61.2014.2.9

DO - 10.1556/AMicr.61.2014.2.9

M3 - Article

C2 - 24939687

AN - SCOPUS:84902794250

VL - 61

SP - 189

EP - 208

JO - Acta Microbiologica et Immunologica Hungarica

JF - Acta Microbiologica et Immunologica Hungarica

SN - 1217-8950

IS - 2

ER -