Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: Phenotype-genotype correlations

P. Lakatos, L. Lakatos, F. Szalay, Claudia Willheim-Polli, Christoph Österreicher, Z. Tulassay, T. Molnár, Walter Reinisch, J. Papp, G. Mózsik, Peter Ferenci, P. Fuszek, P. Vargha, L. Prónai, A. Németh, P. Miheller, A. Kovács, L. Bene, Gyorgy Szekely, B. GasztonyiF. Nagy, J. Lonovics, Laszlo Ujszaszy, Istvan Altorjai, K. Palatka, Gyula G. Kiss, Ferenc Tarnok, Zoltan Dobronte, Z. Erdélyi, T. Pandúr, G. Mester

Research output: Article

116 Citations (Scopus)

Abstract

Aim: To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD. Methods: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included. DNA was screened for possible NOD2/CARD15 mutations by denaturing high-performance liquid chromatography (confirmed by direct sequencing). TLR4 D299G was tested by PCR-RFLP. Results: NOD2/CARD15 mutations were found in 185 patients (35.1%) and in 33 controls (16.5%, Phet = 1.71, 95%CI = 1.12-2.6, P = 0.0001, ORtwo-risk alleles = 25.2, 95%CI = 4.37- , P

Original languageEnglish
Pages (from-to)1489-1495
Number of pages7
JournalWorld Journal of Gastroenterology
Volume11
Issue number10
Publication statusPublished - márc. 14 2005

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Toll-Like Receptor 4
Genetic Association Studies
Crohn Disease
Mutation
Restriction Fragment Length Polymorphisms
Healthy Volunteers
Alleles
High Pressure Liquid Chromatography
Polymerase Chain Reaction
DNA

ASJC Scopus subject areas

  • Gastroenterology

Cite this

@article{c0b6fe6266fd4b4889334abd3b96651d,
title = "Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: Phenotype-genotype correlations",
abstract = "Aim: To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD. Methods: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included. DNA was screened for possible NOD2/CARD15 mutations by denaturing high-performance liquid chromatography (confirmed by direct sequencing). TLR4 D299G was tested by PCR-RFLP. Results: NOD2/CARD15 mutations were found in 185 patients (35.1{\%}) and in 33 controls (16.5{\%}, Phet = 1.71, 95{\%}CI = 1.12-2.6, P = 0.0001, ORtwo-risk alleles = 25.2, 95{\%}CI = 4.37- , P",
keywords = "CARD15, Crohn's disease, Extraintestinal manifestation, NOD2, Phenotype, TLR4",
author = "P. Lakatos and L. Lakatos and F. Szalay and Claudia Willheim-Polli and Christoph {\"O}sterreicher and Z. Tulassay and T. Moln{\'a}r and Walter Reinisch and J. Papp and G. M{\'o}zsik and Peter Ferenci and P. Fuszek and P. Vargha and L. Pr{\'o}nai and A. N{\'e}meth and P. Miheller and A. Kov{\'a}cs and L. Bene and Gyorgy Szekely and B. Gasztonyi and F. Nagy and J. Lonovics and Laszlo Ujszaszy and Istvan Altorjai and K. Palatka and Kiss, {Gyula G.} and Ferenc Tarnok and Zoltan Dobronte and Z. Erd{\'e}lyi and T. Pand{\'u}r and G. Mester",
year = "2005",
month = "3",
day = "14",
language = "English",
volume = "11",
pages = "1489--1495",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "10",

}

TY - JOUR

T1 - Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease

T2 - Phenotype-genotype correlations

AU - Lakatos, P.

AU - Lakatos, L.

AU - Szalay, F.

AU - Willheim-Polli, Claudia

AU - Österreicher, Christoph

AU - Tulassay, Z.

AU - Molnár, T.

AU - Reinisch, Walter

AU - Papp, J.

AU - Mózsik, G.

AU - Ferenci, Peter

AU - Fuszek, P.

AU - Vargha, P.

AU - Prónai, L.

AU - Németh, A.

AU - Miheller, P.

AU - Kovács, A.

AU - Bene, L.

AU - Szekely, Gyorgy

AU - Gasztonyi, B.

AU - Nagy, F.

AU - Lonovics, J.

AU - Ujszaszy, Laszlo

AU - Altorjai, Istvan

AU - Palatka, K.

AU - Kiss, Gyula G.

AU - Tarnok, Ferenc

AU - Dobronte, Zoltan

AU - Erdélyi, Z.

AU - Pandúr, T.

AU - Mester, G.

PY - 2005/3/14

Y1 - 2005/3/14

N2 - Aim: To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD. Methods: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included. DNA was screened for possible NOD2/CARD15 mutations by denaturing high-performance liquid chromatography (confirmed by direct sequencing). TLR4 D299G was tested by PCR-RFLP. Results: NOD2/CARD15 mutations were found in 185 patients (35.1%) and in 33 controls (16.5%, Phet = 1.71, 95%CI = 1.12-2.6, P = 0.0001, ORtwo-risk alleles = 25.2, 95%CI = 4.37- , P

AB - Aim: To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD. Methods: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included. DNA was screened for possible NOD2/CARD15 mutations by denaturing high-performance liquid chromatography (confirmed by direct sequencing). TLR4 D299G was tested by PCR-RFLP. Results: NOD2/CARD15 mutations were found in 185 patients (35.1%) and in 33 controls (16.5%, Phet = 1.71, 95%CI = 1.12-2.6, P = 0.0001, ORtwo-risk alleles = 25.2, 95%CI = 4.37- , P

KW - CARD15

KW - Crohn's disease

KW - Extraintestinal manifestation

KW - NOD2

KW - Phenotype

KW - TLR4

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M3 - Article

C2 - 15770725

AN - SCOPUS:20144387613

VL - 11

SP - 1489

EP - 1495

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 10

ER -