Thioacetamid hepatocarcinogenesis TGF-béta transzgén egereken

Schnur János, Schaff Zsuzsa, Nagy Péter

Research output: Article

Abstract

Purpose: We have investigated the role of transforming growth factor beta-1 (TGF-β1) in thioacetamide induced bepatocarcinogenesis. Methods: Chemical bepatocarcinogenesis experiments were performed on transgenic mice expressing high level of active TGF-β in their liver. Thioacetamide was administered in a dose of300 mg/l in drinking water from four weeks age until sacrifice. Results: The increased TGF-β production has not changed the spontaneous tumor rate in this strain of mice. However it accelerated the thioacetamide induced carcinogenesis, higher incidence of adenomas and carcinomas occurred in transgenic mice. Conclusion: Our observations together with others in the literature underline that the role of TGF-β in carcinogenesis is a complex issue and TGF-β cannot be regarded as a protective factor against tumorigenesis.

Translated title of the contributionThioacetamide induced bepatocarcinogenesis in TGF-beta transgenic mice
Original languageHungarian
Pages (from-to)124-127
Number of pages4
JournalMagyar onkologia
Volume43
Issue number2
Publication statusPublished - dec. 1 1999

ASJC Scopus subject areas

  • Medicine(all)

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