Purpose: We have investigated the role of transforming growth factor beta-1 (TGF-β1) in thioacetamide induced bepatocarcinogenesis. Methods: Chemical bepatocarcinogenesis experiments were performed on transgenic mice expressing high level of active TGF-β in their liver. Thioacetamide was administered in a dose of300 mg/l in drinking water from four weeks age until sacrifice. Results: The increased TGF-β production has not changed the spontaneous tumor rate in this strain of mice. However it accelerated the thioacetamide induced carcinogenesis, higher incidence of adenomas and carcinomas occurred in transgenic mice. Conclusion: Our observations together with others in the literature underline that the role of TGF-β in carcinogenesis is a complex issue and TGF-β cannot be regarded as a protective factor against tumorigenesis.
|Translated title of the contribution||Thioacetamide induced bepatocarcinogenesis in TGF-beta transgenic mice|
|Number of pages||4|
|Publication status||Published - dec. 1 1999|
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