Thin-layer chromatography as analytical method for inclusion complexes of some diuretics with cyclodextrins

Codruta Şoica, A. Gyeresi, Cristina Dehelean, Camelia Peev, Z. Aigner, M. Kata

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6 Citations (Scopus)

Abstract

Thin-layer chromatography has been successfully used for the analysis of cyclodextrín inclusion complexes. As a result of inclusion complexation, the Rf value for stable complexes is significantly lower than Rf values of the active substances. In the present study, thin-layer chromatography was used for the analysis of inclusion complexes of some sulphonamidic diuretics with different structures (chlorthalidone, hydrochlorothiazide, furosemide, indapamide and acetazolamide) with natural and semisynthetic cyclodextrin (β-cyclodextrin, hydroxypropyl- β-cyclodextrin, randomly methylated- β-cyclodextrin). The complexes were obtained by different preparation methods. There was a significant diminution of the Rf values of the complexes compared with the active substances which can be interpreted as the formation of real inclusion complexes.

Original languageEnglish
Pages (from-to)75-82
Number of pages8
JournalFarmacia
Volume56
Issue number1
Publication statusPublished - márc. 20 2008

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ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Şoica, C., Gyeresi, A., Dehelean, C., Peev, C., Aigner, Z., & Kata, M. (2008). Thin-layer chromatography as analytical method for inclusion complexes of some diuretics with cyclodextrins. Farmacia, 56(1), 75-82.