Thermoanalytical method for predicting the hydration effect permanency of dermal semisolid preparations

Eszter Csizmazia, Mária Budai-Szücs, I. Erös, Zsolt Makai, P. Szabó-Révész, Gábor Varju, Erzsébet Csányi

Research output: Article

7 Citations (Scopus)

Abstract

Our aim was to develop potential dermal drug delivery systems (DDSs) with a good and lasting moisturizing effect. Lyotropic liquid crystals (LLCs), gelemulsions and hydrogels were investigated by means of thermogravimetry, which can give information about the structure of these preparations, and we could study the water binding mechanisms indirectly in them. We found that the preparations with a complex structure and strong water bonds hydrate the skin well and lastingly by in vivo tests. Since the thermoanalytical results correlate with the in vivo test results, this method could be suited for predicting the moisturizing effect of the vehicles and provide the possibility to select the potential semisolid DDSs for in vivo tests cost and time effectively.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalJournal of Thermal Analysis and Calorimetry
Volume102
Issue number1
DOIs
Publication statusPublished - okt. 2010

Fingerprint

semisolids
Hydration
hydration
Liquid Crystals
preparation
Hydrogels
Water
delivery
drugs
Hydrates
Thermogravimetric analysis
Skin
thermogravimetry
hydrates
water
vehicles
liquid crystals
costs
Costs
Drug Delivery Systems

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Condensed Matter Physics

Cite this

Thermoanalytical method for predicting the hydration effect permanency of dermal semisolid preparations. / Csizmazia, Eszter; Budai-Szücs, Mária; Erös, I.; Makai, Zsolt; Szabó-Révész, P.; Varju, Gábor; Csányi, Erzsébet.

In: Journal of Thermal Analysis and Calorimetry, Vol. 102, No. 1, 10.2010, p. 313-316.

Research output: Article

Csizmazia, Eszter ; Budai-Szücs, Mária ; Erös, I. ; Makai, Zsolt ; Szabó-Révész, P. ; Varju, Gábor ; Csányi, Erzsébet. / Thermoanalytical method for predicting the hydration effect permanency of dermal semisolid preparations. In: Journal of Thermal Analysis and Calorimetry. 2010 ; Vol. 102, No. 1. pp. 313-316.
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AU - Varju, Gábor

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