Therapeutic potential of exogenous ketone supplement induced ketosis in the treatment of psychiatric disorders: Review of current literature

Z. Kovács, Dominic P. D'Agostino, David Diamond, Mark S. Kindy, Christopher Rogers, Csilla Ari

Research output: Article

1 Citation (Scopus)

Abstract

Globally, psychiatric disorders, such as anxiety disorder, bipolar disorder, schizophrenia, depression, autism spectrum disorder, and attention-deficit/hyperactivity disorder (ADHD) are becoming more prevalent. Although the exact pathological alterations are not yet clear, recent studies have demonstrated that widespread changes of very complex metabolic pathways may partially underlie the pathophysiology of many psychiatric diseases. Thus, more attention should be directed to metabolic-based therapeutic interventions in the treatment of psychiatric disorders. Emerging evidence from numerous studies suggests that administration of exogenous ketone supplements, such as ketone salts or ketone esters, generates rapid and sustained nutritional ketosis and metabolic changes, which may evoke potential therapeutic effects in cases of central nervous system (CNS) disorders, including psychiatric diseases. Therefore, the aim of this review is to summarize the current information on ketone supplementation as a potential therapeutic tool for psychiatric disorders. Ketone supplementation elevates blood levels of the ketone bodies: D-β-hydroxybutyrate (βHB), acetoacetate (AcAc), and acetone. These compounds, either directly or indirectly, beneficially affect the mitochondria, glycolysis, neurotransmitter levels, activity of free fatty acid receptor 3 (FFAR3), hydroxycarboxylic acid receptor 2 (HCAR2), and histone deacetylase, as well as functioning of NOD-like receptor pyrin domain 3 (NLRP3) inflammasome and mitochondrial uncoupling protein (UCP) expression. The result of downstream cellular and molecular changes is a reduction in the pathophysiology associated with various psychiatric disorders. We conclude that supplement-induced nutritional ketosis leads to metabolic changes and improvements, for example, in mitochondrial function and inflammatory processes, and suggest that development of specific adjunctive ketogenic protocols for psychiatric diseases should be actively pursued.

Original languageEnglish
Article number363
JournalFrontiers in Psychiatry
Volume10
Issue numberMAY
DOIs
Publication statusPublished - jan. 1 2019

Fingerprint

Ketosis
Ketones
Psychiatry
Therapeutics
Histone Deacetylase 2
Inflammasomes
Hydroxybutyrates
Ketone Bodies
Central Nervous System Diseases
Therapeutic Uses
Glycolysis
Attention Deficit Disorder with Hyperactivity
Acetone
Metabolic Networks and Pathways
Anxiety Disorders
Bipolar Disorder
Nonesterified Fatty Acids
Neurotransmitter Agents
Schizophrenia
Mitochondria

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Therapeutic potential of exogenous ketone supplement induced ketosis in the treatment of psychiatric disorders : Review of current literature. / Kovács, Z.; D'Agostino, Dominic P.; Diamond, David; Kindy, Mark S.; Rogers, Christopher; Ari, Csilla.

In: Frontiers in Psychiatry, Vol. 10, No. MAY, 363, 01.01.2019.

Research output: Article

Kovács, Z. ; D'Agostino, Dominic P. ; Diamond, David ; Kindy, Mark S. ; Rogers, Christopher ; Ari, Csilla. / Therapeutic potential of exogenous ketone supplement induced ketosis in the treatment of psychiatric disorders : Review of current literature. In: Frontiers in Psychiatry. 2019 ; Vol. 10, No. MAY.
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