The tumor promoter tetradecanoyl-phorbol-acetate (TPA) elicits the redistribution of zinc in subcellular fractions of rabbit thymocytes measured by X-ray fluorescence

Péter Csermely, Sándor Gueth, János Somogyi

Research output: Article

16 Citations (Scopus)

Abstract

Prolonged (90 minutes) incubation with tumor promoter 12-O-tetra-decanoyl-phorbol-13-acetate (TPA) elicits the redistribution of zinc from the nuclear fraction and mitochondria to the cytosol and microsomes in rabbit thymocytes. The zinc redistribution might play a role in the TPA-caused desensitization of T lymphocytes towards calcium and in the TPA-induced inhibition of G1S phase transition and cytotoxicity of T lymphocytes.

Original languageEnglish
Pages (from-to)863-868
Number of pages6
JournalBiochemical and biophysical research communications
Volume144
Issue number2
DOIs
Publication statusPublished - ápr. 29 1987

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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