The synthesis of (3,4,5,6-tetrahydro-4-oxo-2h-1,3-thiazin-2-yl)-alkanoic acids, their derivatives and some related compounds

J. Nyitrai, J. Fetter, Gy Hornyák, K. Zauer, K. Lempert, I. Koczka, I. Sági, Cs Rétháti

Research output: Article

12 Citations (Scopus)

Abstract

5,6-Dihydro-2H-1,3-thiazin-4(3H)-ones 2-10 related to the natural antituberculytic Mycobacidine 1, have been synthesised. Some of the compounds of types 2,3 and 5 proved highly active in vitro against Mycobacterium tuberculosis typ. humanus (H37Rv), but the in vitro activities are diminished or suspended in the presence of biotine.

Original languageEnglish
Pages (from-to)1031-1035
Number of pages5
JournalTetrahedron
Volume34
Issue number7
DOIs
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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