The serine protease granzyme M is preferentially expressed in NK-cell, γδ T-cell, and intestinal T-cell lymphomas: Evidence of origin from lymphocytes involved in innate immunity

Laszlo Krenacs, Mark J. Smyth, Eniko Bagdi, Tibor Krenacs, Laszlo Kopper, Thomas Rudiger, Andreas Zettl, Hans Konrad Muller-Hermelink, Elaine S. Jaffe, Mark Raffeld

Research output: Article

67 Citations (Scopus)

Abstract

Granzyme M (GM) is a novel serine protease whose expression is highly restricted to natural killer (NK) cells, CD3+CD56+ T cells, and γδ T cells. Using a GM-specific monoclonal antibody, we analyzed the expression of GM in 214 mature T-cell and NK-cell lymphomas. GM was preferentially expressed in nasal NK/T-cell lymphomas (100%), γδ T-cell lymphomas (100%), and intestinal T-cell lymphomas (85%). In contrast, GM expression was present at low prevalence in mycosis fungoides/Sézary syndrome (3%), anaplastic large-cell lymphoma (6%), panniculitis-like T-cell lymphoma (11%), and angioimmunoblastic T-cell lymphoma (0%) cases. Peripheral T-cell lymphomas of unspecified subtype showed an intermediate frequency (37%) of GM expression, consistent with their heterogeneous origin. We conclude that GM expression is a distinctive feature of the nasal NK/T-cell, γδ T-cell, and intestinal T-cell lymphomas, and suggest that these tumors develop from lymphocytes involved in innate immunity.

Original languageEnglish
Pages (from-to)3590-3593
Number of pages4
JournalBlood
Volume101
Issue number9
DOIs
Publication statusPublished - máj. 1 2003

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ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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