The role of nitric oxide in passive avoidance learning

G. Telegdy, R. Kokavszky

Research output: Article

45 Citations (Scopus)

Abstract

The role of nitric oxide on passive avoidance learning was studied by administering L-arginine or D-arginine to male rats in a passive avoidance paradigm. L-Arginine administered into the lateral brain ventricle at a dose of 1.25 μg showed a tendency to increase the passive avoidance latency, and 2.5 μg exerted almost maximal action, but the action gradually increased still further up to 20 μg tested. D-Arginine had no action. Peripheral administration (intraperitoneal) of L-arginine facilitated the consolidation of passive avoidance learning in a dose-dependent manner. A significant increase in passive avoidance response was obtained following an injection of 100 mg/kg L-arginine. When L-arginine was given i.c.v. with a selected dose of 5 μg, 30 min prior to a learning trial, the latency of the passsive avoidance response was likewise lengthened. However, when L-arginine was given 30 min before the 24-hr testing (retrieval), it was ineffective. It was also ineffective when given 6 hr after the training trial. However, when L-arginine was administered immediately following the training trial, the action in improving the consolidation could be detected 6 hr after the training trial. Nitro-L-arginine, which blocks nitric oxide synthase, can also block the facilitation of consolidation caused by the nitic oxide donor L-arginine. The nitric oxide synthase inhibitor per se in different doses had no action on the leaarning of a passive avoidance task. The results indicate that nitric oxide is able to facilitate the learning and comsolidation of memory in a passive avoidance paradigm, but it is ineffective in retrieval processes. The results also suggest that, under the experimental circumstances used, nitric oxide is involved only in the facilitated learning and memory processses caused by pharmacological effect of L-arginine, and not involved in normal learning processes.

Original languageEnglish
Pages (from-to)1583-1587
Number of pages5
JournalNeuropharmacology
Volume36
Issue number11-12
DOIs
Publication statusPublished - 1997

Fingerprint

Avoidance Learning
Arginine
Nitric Oxide
Learning
Nitric Oxide Synthase
Lateral Ventricles
Oxides

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

The role of nitric oxide in passive avoidance learning. / Telegdy, G.; Kokavszky, R.

In: Neuropharmacology, Vol. 36, No. 11-12, 1997, p. 1583-1587.

Research output: Article

Telegdy, G. ; Kokavszky, R. / The role of nitric oxide in passive avoidance learning. In: Neuropharmacology. 1997 ; Vol. 36, No. 11-12. pp. 1583-1587.
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