The role of neural cell adhesion molecules in plasticity and repair

J. Z. Kiss, E. Troncoso, Z. Djebbara, L. Vutskits, D. Muller

Research output: Article

122 Citations (Scopus)

Abstract

Repair and functional recovery after critically depends on structural and functional plasticity of preserved neuronal networks. A striking feature of brain structures where tissue reorganization and plasticity occur is a strong expression of the polysialylated neural cell adhesion molecule (PSA-NCAM). An important role of this molecule in various aspects of neuronal and synaptic plasticity has been revealed by many studies. Recently, a new mechanism has been elucidated whereby PSA-NCAM may contribute to signalling mediated by the neurotrophic factor BDNF, thereby sensitizing neurons to this growth factor. This mechanism was shown to be important for activity-induced synaptic plasticity and for the survival and differentiation of cortical neurons. A cross-talk between these molecules may, thus, reveal a key factor for properties of structural plasticity and in particular could mediate the activity-dependent aspects of synaptic network remodeling. Animal models have been developed to assess the role of these molecules in functional recovery after lesions.

Original languageEnglish
Pages (from-to)175-184
Number of pages10
JournalBrain Research Reviews
Volume36
Issue number2-3
DOIs
Publication statusPublished - jan. 1 2001

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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