Az extracelluláris mátrix komponensek tumorinvá zióban betöltött szerepe intrakraniális daganatokban

Research output: Review article

6 Citations (Scopus)


The usual local recurrence of primary brain tumors is mainly due to the infiltration of adjacent brain parenchyma by the glioma cells. This invasive feature of the tumors makes total surgical excision impossible and also decreases the efficacy of focal radiotherapy. Interestingly, intracerebral metastases originating from many anaplastic tumors of other organs perform very moderate peritumoral infiltration, therefore radical resection can be routinely achieved and focal irradiation, even stereotactic radiotherapy, provides good tumor control. Differences in the effectiveness of treatment between the two tumor types derive from the remarkably different extent of peritumoral infiltration. Thus significant molecular biological research has been dealing with the infiltrative activity of various brain tumors and many attempts were made to develop anti-invasive drugs for oncotherapy. This review summarizes the results of these studies, describing cellular and molecular events of brain tumor invasion and according potential oncotherapeutic possibilities.

Translated title of the contributionThe role of extracellular matrix components in the invasion of intracranial malignancies
Original languageHungarian
Pages (from-to)222-231
Number of pages10
JournalMagyar onkologia
Issue number4
Publication statusPublished - 2013


  • Brain tumor
  • Extracellular matrix
  • Glioma
  • Invasion
  • Oncotherapy

ASJC Scopus subject areas

  • Medicine(all)

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