A nem szteroid gyulladáscsökkentok kockázatai

Csaba Farsang, J. Róbert Bedros, Sándor Alföldi

Research output: Article

1 Citation (Scopus)

Abstract

Nonsteroidal antiinflammatory drugs (NSAIDs) are among the most frequently used medicines all over the world. In the year 2012 in the LAM, we summarized data on cardiovascular (CV) safety of these drugs. We emphasized that all NSAIDs may potentially be harmful on the CV system, as they can increase the blood pressure, the risk of coronary events (angina, myocardial infarction), and that of stroke, as well as they may deteriorate renal functions. We also outlined that in this respect there are substantial differences between different compounds, and the CV risk does not depend on the ratio of COX-1/COX-2 selectivity. The newly available data of original papers and metaanalyses shed light on further details. Even naproxen which drug was previously considered the less harmful on CV system can increase the risk of blood pressure, stroke, and gastrointestinal (GI) complications. We have to emphasize that the most important risk of NSAIDs is still the GI bleeding. This adverse effect is significantly less for drugs which are more selective for COX-2 than COX-1 enzyme, but other, pleiotropic effects can also beneficially modify the GI as well as the CV risk. E.g. The aceclofenac was found to be among NSAIDs with the less adverse effects on GI system and is also among those having the less CV risk.

Translated title of the contributionThe risk of nonsteroidal antiinflammatory drugs
Original languageHungarian
Pages (from-to)327-332
Number of pages6
JournalLege Artis Medicinae
Volume24
Issue number7
Publication statusPublished - 2014

Keywords

  • Cardiovascular risk
  • Gastrointestinal risk
  • Nonsteroidal antiinflammatory drugs
  • Renal risk

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Farsang, C., Bedros, J. R., & Alföldi, S. (2014). A nem szteroid gyulladáscsökkentok kockázatai. Lege Artis Medicinae, 24(7), 327-332.