The response of plasma catecholamines in rats simultaneously exposed to immobilization and painful stimuli

Boris Mravec, Andrej Tillinger, Ibolya Bodnar, György M. Nagy, Miklos Palkovits, Richard Kvetňanský

Research output: Conference contribution

11 Citations (Scopus)

Abstract

Immobilization represents a strong stressor inducing a profound increase in plasma epinephrine and norepinephrine levels. We have previously demonstrated that a subcutaneous injection of formalin (0.2 mL of 4% solution/100 g bw) attenuated the immobilization-induced elevation of plasma epinephrine levels in rats. In the present study, we investigated whether other painful and stressful stimuli, such as capsaicin, hydrochloric acid, mechanical pressure, heat, and cold, might also attenuate the increase of plasma epinephrine in rats exposed to acute immobilization stress. With the exception of formalin, all of the painful stimuli applied failed to attenuate the increase of plasma epinephrine levels in immobilized animals. Our data suggest that the attenuation of an immobilization-induced increase in plasma epinephrine levels is specific for subcutaneous formalin administration.

Original languageEnglish
Title of host publicationStress, Neurotransmitters, and Hormones Neuroendocrine and Genetic Mechanisms
PublisherBlackwell Publishing Inc.
Pages196-200
Number of pages5
ISBN (Print)9781573316927
DOIs
Publication statusPublished - dec. 2008

Publication series

NameAnnals of the New York Academy of Sciences
Volume1148
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Fingerprint Dive into the research topics of 'The response of plasma catecholamines in rats simultaneously exposed to immobilization and painful stimuli'. Together they form a unique fingerprint.

  • Cite this

    Mravec, B., Tillinger, A., Bodnar, I., Nagy, G. M., Palkovits, M., & Kvetňanský, R. (2008). The response of plasma catecholamines in rats simultaneously exposed to immobilization and painful stimuli. In Stress, Neurotransmitters, and Hormones Neuroendocrine and Genetic Mechanisms (pp. 196-200). (Annals of the New York Academy of Sciences; Vol. 1148). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1410.010