The relationship of multifocality and tumor burden with various tumor characteristics and survival in early breast cancer

G. Kelemen, V. Farkas, J. Debrah, K. Ormandi, A. Voros, L. Kaizer, Z. Varga, G. Lazar, Z. Kahán

Research output: Article

2 Citations (Scopus)

Abstract

The presence of multifocality and the aggregate tumor size were retrospectively analysed in a database of 1071 operated breast cancers. Around a quarter of all these cancers involved multiple foci, while a tenth of the total demonstrated more than one invasive focus. Although the multifocal cancers were smaller and more often screen-detected than the unifocal cancers, their aggregate tumor size was larger, and they more frequently displayed casting-type calcifications in the mammogram and HER2 positivity. Lobular histology favoured larger tumor burden. The invasive multifocal cancers were more commonly lymph node-positive than the other tumors. In a subgroup of 584 patients with a median follow-up time of 5 years, the larger size of the invasive tumor, the presence of LVI or lymph node involvement, HER2 positivity and triple negativity were associated with a poorer RFS and OS, while the outcome of screen-detected tumors was superior to that of non-screendetected or interval cancers. A large tumor size, lymph node positivity and HER2 positive or triple negative phenotypes were independent determinants of a poorer survival rate.

Original languageEnglish
Pages (from-to)566-573
Number of pages8
JournalNeoplasma
Volume59
Issue number5
DOIs
Publication statusPublished - 2012

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Tumor Burden
Breast Neoplasms
Survival
Neoplasms
Lymph Nodes
Histology
Survival Rate
Databases
Phenotype

ASJC Scopus subject areas

  • Cancer Research

Cite this

The relationship of multifocality and tumor burden with various tumor characteristics and survival in early breast cancer. / Kelemen, G.; Farkas, V.; Debrah, J.; Ormandi, K.; Voros, A.; Kaizer, L.; Varga, Z.; Lazar, G.; Kahán, Z.

In: Neoplasma, Vol. 59, No. 5, 2012, p. 566-573.

Research output: Article

Kelemen, G. ; Farkas, V. ; Debrah, J. ; Ormandi, K. ; Voros, A. ; Kaizer, L. ; Varga, Z. ; Lazar, G. ; Kahán, Z. / The relationship of multifocality and tumor burden with various tumor characteristics and survival in early breast cancer. In: Neoplasma. 2012 ; Vol. 59, No. 5. pp. 566-573.
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