The prevalence of ADH1B and OPRM1 alleles predisposing for alcohol consumption are increased in the Hungarian psoriasis population

Zita Szentkereszty-Kovács, Szilvia Fiatal, A. Szegedi, Dóra Kovács, Eszter Janka, Krisztina Herszényi, Péter Holló, Pernilla Nikamo, Mona Ståhle, E. Remenyik, D. Törőcsik

Research output: Article

Abstract

Alcohol intake affects in great the symptoms and life of psoriasis patients, although the association of SNPs related to increased alcohol consumption with psoriasis has not been elucidated. Therefore, to investigate the association of psoriasis with established alcohol consumption and dependence-related gene variants we conducted a population-based case–control study including 3743 subjects (776 psoriasis cases and 2967 controls from the general Hungarian population). Genotyping of 23 SNPs at ADH1B, ADH1C, ALDH1A1, ALDH2, SLC6A3, DDC, GABRA2, GABRG1, HTR1B, MAOA, TPH2, CHRM2, GRIN2A, POMC, OPRM1, OPRK1 and BDNF were determined and differences in genotype and allele distributions were investigated. Multiple logistic regression analyses were implemented. Analysis revealed association between C allele of the rs1229984 polymorphism (ADH1B gene) and psoriasis risk (OR additive = 1.58, 95% CI 1.23–2.03, p < 0.001, OR recessive = 1.58, 95% CI 1.22–2.04, p = 0.001). Furthermore, the G allele of rs1799971 polymorphism (OPRM1 gene) increased the risk of familial aggregation (OR additive = 1.99, 95% CI 1.36–2.91, p < 0.001 OR dominant = 2.01, 95% CI 1.35–3.01, p < 0.001). In subgroups of psoriatic patients with history of early onset and familial aggregation effect allele ‘C’ of rs1229984 showed association in the additive and recessive models (OR additive = 2.41, 95% CI 1.26–4.61, p < 0.01, OR recessive = 2.42, 95% CI 1.26–4.68, p < 0.01). While effect allele ‘G’ of rs1799971 (OPRM1) also associated with increased risk of early onset and familial aggregation of psoriasis in the additive and dominant models (OR additive = 1.75, 95% CI 1.27–2.43, p = 0.001, OR dominant = 1.82, 95% CI 1.26–2.63, p = 0.001). Our results suggest that genetically defined high-risk individuals for alcohol consumption are more common in the psoriasis population.

Original languageEnglish
JournalArchives of Dermatological Research
DOIs
Publication statusPublished - jan. 1 2019

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Psoriasis
Alcohol Drinking
Alleles
Population
Single Nucleotide Polymorphism
Genes
Pro-Opiomelanocortin
Brain-Derived Neurotrophic Factor
Alcoholism
Logistic Models
Genotype
Regression Analysis
Alcohols

ASJC Scopus subject areas

  • Dermatology

Cite this

The prevalence of ADH1B and OPRM1 alleles predisposing for alcohol consumption are increased in the Hungarian psoriasis population. / Szentkereszty-Kovács, Zita; Fiatal, Szilvia; Szegedi, A.; Kovács, Dóra; Janka, Eszter; Herszényi, Krisztina; Holló, Péter; Nikamo, Pernilla; Ståhle, Mona; Remenyik, E.; Törőcsik, D.

In: Archives of Dermatological Research, 01.01.2019.

Research output: Article

Szentkereszty-Kovács, Zita ; Fiatal, Szilvia ; Szegedi, A. ; Kovács, Dóra ; Janka, Eszter ; Herszényi, Krisztina ; Holló, Péter ; Nikamo, Pernilla ; Ståhle, Mona ; Remenyik, E. ; Törőcsik, D. / The prevalence of ADH1B and OPRM1 alleles predisposing for alcohol consumption are increased in the Hungarian psoriasis population. In: Archives of Dermatological Research. 2019.
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title = "The prevalence of ADH1B and OPRM1 alleles predisposing for alcohol consumption are increased in the Hungarian psoriasis population",
abstract = "Alcohol intake affects in great the symptoms and life of psoriasis patients, although the association of SNPs related to increased alcohol consumption with psoriasis has not been elucidated. Therefore, to investigate the association of psoriasis with established alcohol consumption and dependence-related gene variants we conducted a population-based case–control study including 3743 subjects (776 psoriasis cases and 2967 controls from the general Hungarian population). Genotyping of 23 SNPs at ADH1B, ADH1C, ALDH1A1, ALDH2, SLC6A3, DDC, GABRA2, GABRG1, HTR1B, MAOA, TPH2, CHRM2, GRIN2A, POMC, OPRM1, OPRK1 and BDNF were determined and differences in genotype and allele distributions were investigated. Multiple logistic regression analyses were implemented. Analysis revealed association between C allele of the rs1229984 polymorphism (ADH1B gene) and psoriasis risk (OR additive = 1.58, 95{\%} CI 1.23–2.03, p < 0.001, OR recessive = 1.58, 95{\%} CI 1.22–2.04, p = 0.001). Furthermore, the G allele of rs1799971 polymorphism (OPRM1 gene) increased the risk of familial aggregation (OR additive = 1.99, 95{\%} CI 1.36–2.91, p < 0.001 OR dominant = 2.01, 95{\%} CI 1.35–3.01, p < 0.001). In subgroups of psoriatic patients with history of early onset and familial aggregation effect allele ‘C’ of rs1229984 showed association in the additive and recessive models (OR additive = 2.41, 95{\%} CI 1.26–4.61, p < 0.01, OR recessive = 2.42, 95{\%} CI 1.26–4.68, p < 0.01). While effect allele ‘G’ of rs1799971 (OPRM1) also associated with increased risk of early onset and familial aggregation of psoriasis in the additive and dominant models (OR additive = 1.75, 95{\%} CI 1.27–2.43, p = 0.001, OR dominant = 1.82, 95{\%} CI 1.26–2.63, p = 0.001). Our results suggest that genetically defined high-risk individuals for alcohol consumption are more common in the psoriasis population.",
keywords = "ADH1B gene, Alcohol consumption, OPRM1 gene, Population genetics, Psoriasis",
author = "Zita Szentkereszty-Kov{\'a}cs and Szilvia Fiatal and A. Szegedi and D{\'o}ra Kov{\'a}cs and Eszter Janka and Krisztina Hersz{\'e}nyi and P{\'e}ter Holl{\'o} and Pernilla Nikamo and Mona St{\aa}hle and E. Remenyik and D. T{\"o}rőcsik",
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T1 - The prevalence of ADH1B and OPRM1 alleles predisposing for alcohol consumption are increased in the Hungarian psoriasis population

AU - Szentkereszty-Kovács, Zita

AU - Fiatal, Szilvia

AU - Szegedi, A.

AU - Kovács, Dóra

AU - Janka, Eszter

AU - Herszényi, Krisztina

AU - Holló, Péter

AU - Nikamo, Pernilla

AU - Ståhle, Mona

AU - Remenyik, E.

AU - Törőcsik, D.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Alcohol intake affects in great the symptoms and life of psoriasis patients, although the association of SNPs related to increased alcohol consumption with psoriasis has not been elucidated. Therefore, to investigate the association of psoriasis with established alcohol consumption and dependence-related gene variants we conducted a population-based case–control study including 3743 subjects (776 psoriasis cases and 2967 controls from the general Hungarian population). Genotyping of 23 SNPs at ADH1B, ADH1C, ALDH1A1, ALDH2, SLC6A3, DDC, GABRA2, GABRG1, HTR1B, MAOA, TPH2, CHRM2, GRIN2A, POMC, OPRM1, OPRK1 and BDNF were determined and differences in genotype and allele distributions were investigated. Multiple logistic regression analyses were implemented. Analysis revealed association between C allele of the rs1229984 polymorphism (ADH1B gene) and psoriasis risk (OR additive = 1.58, 95% CI 1.23–2.03, p < 0.001, OR recessive = 1.58, 95% CI 1.22–2.04, p = 0.001). Furthermore, the G allele of rs1799971 polymorphism (OPRM1 gene) increased the risk of familial aggregation (OR additive = 1.99, 95% CI 1.36–2.91, p < 0.001 OR dominant = 2.01, 95% CI 1.35–3.01, p < 0.001). In subgroups of psoriatic patients with history of early onset and familial aggregation effect allele ‘C’ of rs1229984 showed association in the additive and recessive models (OR additive = 2.41, 95% CI 1.26–4.61, p < 0.01, OR recessive = 2.42, 95% CI 1.26–4.68, p < 0.01). While effect allele ‘G’ of rs1799971 (OPRM1) also associated with increased risk of early onset and familial aggregation of psoriasis in the additive and dominant models (OR additive = 1.75, 95% CI 1.27–2.43, p = 0.001, OR dominant = 1.82, 95% CI 1.26–2.63, p = 0.001). Our results suggest that genetically defined high-risk individuals for alcohol consumption are more common in the psoriasis population.

AB - Alcohol intake affects in great the symptoms and life of psoriasis patients, although the association of SNPs related to increased alcohol consumption with psoriasis has not been elucidated. Therefore, to investigate the association of psoriasis with established alcohol consumption and dependence-related gene variants we conducted a population-based case–control study including 3743 subjects (776 psoriasis cases and 2967 controls from the general Hungarian population). Genotyping of 23 SNPs at ADH1B, ADH1C, ALDH1A1, ALDH2, SLC6A3, DDC, GABRA2, GABRG1, HTR1B, MAOA, TPH2, CHRM2, GRIN2A, POMC, OPRM1, OPRK1 and BDNF were determined and differences in genotype and allele distributions were investigated. Multiple logistic regression analyses were implemented. Analysis revealed association between C allele of the rs1229984 polymorphism (ADH1B gene) and psoriasis risk (OR additive = 1.58, 95% CI 1.23–2.03, p < 0.001, OR recessive = 1.58, 95% CI 1.22–2.04, p = 0.001). Furthermore, the G allele of rs1799971 polymorphism (OPRM1 gene) increased the risk of familial aggregation (OR additive = 1.99, 95% CI 1.36–2.91, p < 0.001 OR dominant = 2.01, 95% CI 1.35–3.01, p < 0.001). In subgroups of psoriatic patients with history of early onset and familial aggregation effect allele ‘C’ of rs1229984 showed association in the additive and recessive models (OR additive = 2.41, 95% CI 1.26–4.61, p < 0.01, OR recessive = 2.42, 95% CI 1.26–4.68, p < 0.01). While effect allele ‘G’ of rs1799971 (OPRM1) also associated with increased risk of early onset and familial aggregation of psoriasis in the additive and dominant models (OR additive = 1.75, 95% CI 1.27–2.43, p = 0.001, OR dominant = 1.82, 95% CI 1.26–2.63, p = 0.001). Our results suggest that genetically defined high-risk individuals for alcohol consumption are more common in the psoriasis population.

KW - ADH1B gene

KW - Alcohol consumption

KW - OPRM1 gene

KW - Population genetics

KW - Psoriasis

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