The potential role of HLA-DRB1∗11 in the development and outcome of haematopoietic stem cell transplantation-associated thrombotic microangiopathy

K. Balassa, H. Andrikovics, P. Remenyi, A. Batai, A. Bors, K. P. Kiss, A. Szilvasi, K. Rajczy, D. Inotai, L. Gopcsa, L. Lengyel, A. Barta, M. Reti, A. Tordai, T. Masszi

Research output: Article

13 Citations (Scopus)

Abstract

Transplantation-associated thrombotic microangiopathy (TA-TMA) is a serious complication of allogeneic haematopoietic stem cell transplantation (allo-HSCT) with high mortality rate. We retrospectively studied the frequency, clinical and genetic associations and prognostic effect of TA-TMA, in a total of 425 consecutive adult patients, who underwent allo-HSCT for a malignant haematological condition between 2007 and 2013 at our single centre. TA-TMA developed in 19% of the patients. Unrelated donor type (P<0.001), acute GvHD grades II-IV (P<0.001), myeloablative conditioning regimens (P=0.003), tacrolimus-based GvHD prophylaxis (P=0.003), CMV infection (P=0.003) and carriership for HLA-DRB1∗11 (P=0.034) were associated with the development of TA-TMA. Survival was adversely affected by the presence of TA-TMA (P<0.001). Among patients with TA-TMA, the outcome of HLA-DRB1∗11 carriers was significantly better compared with non-carriers (P=0.003). As a new finding, our observations suggest that the presence of HLA-DRB1∗11 antigen contributes to the development of TA-TMA and affects the outcome.

Original languageEnglish
Pages (from-to)1321-1325
Number of pages5
JournalBone Marrow Transplantation
Volume50
Issue number10
DOIs
Publication statusPublished - okt. 1 2015

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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