The irritant effects of pharmaceutically applied surfactants

Gábor Eros, Zsuzsanna Kurgyis, István Balázs Németh, Eszter Csizmazia, Szilvia Berkó, P. Szabó-Révész, L. Kemény, Erzsébet Csanyi

Research output: Article

4 Citations (Scopus)

Abstract

Dermal or transdermal medication may lead to irritant contact dermatitis. However, little information is available on the irritant effect of surfactants which are applied in topical formulations. Our aim was to examine the irritant effect of the most frequent compounds in topical products. A murine model was applied. The following compounds were examined: sodium lauryl sulphate (SLS), polyethoxylated (40EO) hydrogenated castor oil and sucrose laurate. SLS led to severe erythema, increase in transepidermal water loss (TEWL) and induced necrosis and accumulation of neutrophylic granulocytes and lymphocytes. Exposure to sucrose laurate resulted in an elevation of TEWL, but histology did not reveal impairment of the skin structure. Application of polyethoxylated (40EO) hydrogenated castor oil was not accompanied by tissue damage. Special attention should be paid to the irritant effect of SLS. Polyethoxylated (40EO) hydrogenated castor oil seems to be a non-irritant agent and sucrose laurate is also a promising candidate for application in topical preparations.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalJournal of Surfactants and Detergents
Volume17
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

sucrose monolaurate
castor oil
Irritants
sucrose
Sodium dodecyl sulfate
Sugar (sucrose)
Castor Oil
sodium sulfates
Surface-Active Agents
water loss
Surface active agents
surfactants
Sodium Dodecyl Sulfate
contact dermatitis
Dermatitis
Histology
histology
Lymphocytes
necrosis
lymphocytes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Chemical Engineering(all)
  • Surfaces, Coatings and Films

Cite this

Eros, G., Kurgyis, Z., Németh, I. B., Csizmazia, E., Berkó, S., Szabó-Révész, P., ... Csanyi, E. (2014). The irritant effects of pharmaceutically applied surfactants. Journal of Surfactants and Detergents, 17(1), 67-70. https://doi.org/10.1007/s11743-013-1444-6

The irritant effects of pharmaceutically applied surfactants. / Eros, Gábor; Kurgyis, Zsuzsanna; Németh, István Balázs; Csizmazia, Eszter; Berkó, Szilvia; Szabó-Révész, P.; Kemény, L.; Csanyi, Erzsébet.

In: Journal of Surfactants and Detergents, Vol. 17, No. 1, 2014, p. 67-70.

Research output: Article

Eros, Gábor ; Kurgyis, Zsuzsanna ; Németh, István Balázs ; Csizmazia, Eszter ; Berkó, Szilvia ; Szabó-Révész, P. ; Kemény, L. ; Csanyi, Erzsébet. / The irritant effects of pharmaceutically applied surfactants. In: Journal of Surfactants and Detergents. 2014 ; Vol. 17, No. 1. pp. 67-70.
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