Abstract
Dermal or transdermal medication may lead to irritant contact dermatitis. However, little information is available on the irritant effect of surfactants which are applied in topical formulations. Our aim was to examine the irritant effect of the most frequent compounds in topical products. A murine model was applied. The following compounds were examined: sodium lauryl sulphate (SLS), polyethoxylated (40EO) hydrogenated castor oil and sucrose laurate. SLS led to severe erythema, increase in transepidermal water loss (TEWL) and induced necrosis and accumulation of neutrophylic granulocytes and lymphocytes. Exposure to sucrose laurate resulted in an elevation of TEWL, but histology did not reveal impairment of the skin structure. Application of polyethoxylated (40EO) hydrogenated castor oil was not accompanied by tissue damage. Special attention should be paid to the irritant effect of SLS. Polyethoxylated (40EO) hydrogenated castor oil seems to be a non-irritant agent and sucrose laurate is also a promising candidate for application in topical preparations.
| Original language | English |
|---|---|
| Pages (from-to) | 67-70 |
| Number of pages | 4 |
| Journal | Journal of Surfactants and Detergents |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 |
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ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Chemical Engineering(all)
- Surfaces, Coatings and Films
Cite this
The irritant effects of pharmaceutically applied surfactants. / Eros, Gábor; Kurgyis, Zsuzsanna; Németh, István Balázs; Csizmazia, Eszter; Berkó, Szilvia; Szabó-Révész, P.; Kemény, L.; Csanyi, Erzsébet.
In: Journal of Surfactants and Detergents, Vol. 17, No. 1, 2014, p. 67-70.Research output: Article
}
TY - JOUR
T1 - The irritant effects of pharmaceutically applied surfactants
AU - Eros, Gábor
AU - Kurgyis, Zsuzsanna
AU - Németh, István Balázs
AU - Csizmazia, Eszter
AU - Berkó, Szilvia
AU - Szabó-Révész, P.
AU - Kemény, L.
AU - Csanyi, Erzsébet
PY - 2014
Y1 - 2014
N2 - Dermal or transdermal medication may lead to irritant contact dermatitis. However, little information is available on the irritant effect of surfactants which are applied in topical formulations. Our aim was to examine the irritant effect of the most frequent compounds in topical products. A murine model was applied. The following compounds were examined: sodium lauryl sulphate (SLS), polyethoxylated (40EO) hydrogenated castor oil and sucrose laurate. SLS led to severe erythema, increase in transepidermal water loss (TEWL) and induced necrosis and accumulation of neutrophylic granulocytes and lymphocytes. Exposure to sucrose laurate resulted in an elevation of TEWL, but histology did not reveal impairment of the skin structure. Application of polyethoxylated (40EO) hydrogenated castor oil was not accompanied by tissue damage. Special attention should be paid to the irritant effect of SLS. Polyethoxylated (40EO) hydrogenated castor oil seems to be a non-irritant agent and sucrose laurate is also a promising candidate for application in topical preparations.
AB - Dermal or transdermal medication may lead to irritant contact dermatitis. However, little information is available on the irritant effect of surfactants which are applied in topical formulations. Our aim was to examine the irritant effect of the most frequent compounds in topical products. A murine model was applied. The following compounds were examined: sodium lauryl sulphate (SLS), polyethoxylated (40EO) hydrogenated castor oil and sucrose laurate. SLS led to severe erythema, increase in transepidermal water loss (TEWL) and induced necrosis and accumulation of neutrophylic granulocytes and lymphocytes. Exposure to sucrose laurate resulted in an elevation of TEWL, but histology did not reveal impairment of the skin structure. Application of polyethoxylated (40EO) hydrogenated castor oil was not accompanied by tissue damage. Special attention should be paid to the irritant effect of SLS. Polyethoxylated (40EO) hydrogenated castor oil seems to be a non-irritant agent and sucrose laurate is also a promising candidate for application in topical preparations.
KW - Anionic surfactants
KW - Application of surfactants
KW - Non-ionic surfactants
UR - http://www.scopus.com/inward/record.url?scp=84899464156&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899464156&partnerID=8YFLogxK
U2 - 10.1007/s11743-013-1444-6
DO - 10.1007/s11743-013-1444-6
M3 - Article
AN - SCOPUS:84899464156
VL - 17
SP - 67
EP - 70
JO - Journal of Surfactants and Detergents
JF - Journal of Surfactants and Detergents
SN - 1097-3958
IS - 1
ER -