The involvement of mitochondria in the pathogenesis of multiple sclerosis

Research output: Review article

76 Citations (Scopus)

Abstract

Multiple sclerosis is an immune-mediated disorder of the central nervous system. Major pathological characteristics include the loss of oligodendrocytes, demyelination and neuroaxonal depletion in association with inflammation. The complex pathophysiology of tissue loss is only partially understood. Here we discuss a variety of mitochondrion-driven mechanisms involved in immune regulation, oligodendrocyte depletion and neurodegeneration. The recognition of a mitochondrial link between inflammation and neurodegeneration underscores the importance of an early aggressive intervention for halting inflammation and preventing neurodegeneration, and identifies the mitochondrion as a potential target in neuroprotection.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalJournal of Neuroimmunology
Volume188
Issue number1-2
DOIs
Publication statusPublished - aug. 1 2007

    Fingerprint

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this