The influence of synthetic modifications in ring C of morphine on opioid activity and receptor sensitivity

S. Furst, T. Friedmann, S. Hosztafi

Research output: Conference contribution

1 Citation (Scopus)

Abstract

6-azido-substituted dihydroisomorphine derivatives proved to be 40-800 times more potent analgesics than their parent molecules. The agonist effects appeared to be mediated by μ receptor, since they were readily antagonized by naloxone. The N-substituted members were found to act as μ antagonists or mixed μ antagonist/κ agonists.

Original languageEnglish
Title of host publicationNew leads in opioid research
Subtitle of host publicationproceedings of the International Narcotics Research Conference. ICS914
EditorsJ.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
PublisherElsevier Science Publishers B.V.
Pages76-77
Number of pages2
ISBN (Print)044481213X
Publication statusPublished - jan. 1 1990
EventThe International Narcotics Research Conference -
Duration: júl. 8 1989júl. 13 1989

Publication series

NameNew leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914

Other

OtherThe International Narcotics Research Conference
Period7/8/897/13/89

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Furst, S., Friedmann, T., & Hosztafi, S. (1990). The influence of synthetic modifications in ring C of morphine on opioid activity and receptor sensitivity. In J. M. Van Ree, A. H. Mulder, V. M. Wiegant, T. B. Van Wimersma Greidanus, J. M. Van Ree, A. H. Mulder, V. M. Wiegant, & T. B. Van Wimersma Greidanus (Eds.), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914 (pp. 76-77). (New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914). Elsevier Science Publishers B.V..