The combined effect of randomly-methylated-â-cyclodextrin (RAMEB) and polyvinylpyrrolidone (PVP) on the solubility of furosemide (FS) was studied. Different molar ratios (1:1, 1:2) and various preparation methods (physical mixing, kneading, ultrasonication) were used for the preparation of the complexes, and a quantity of 15% of PVP was added. The ternary inclusion complexes were analyzed by in vitro dissolution tests, differential scanning calorimetry, in vitro membrane diffusion and X-ray diffraction. The presence of RAMEB and PVP strongly influences different parameters of furosemide: solubility, dissolution, leading to the possibility of obtaining new pharmaceutical preparations, with a greater bioavailability.
|Number of pages||5|
|Journal||Revista de Chimie|
|Publication status||Published - júl. 2006|
ASJC Scopus subject areas
- Materials Science (miscellaneous)
- Surfaces, Coatings and Films
- Materials Chemistry