The influence of polyvinylpyrrolidone on furosemide complexation with randomly-methylated-β-cyclodextrin

Codruţa Şoica, Árpad Gyéresi, Zoltan Aigner, Mihaly Kata, Cristina Dehelean

Research output: Article

3 Citations (Scopus)

Abstract

The combined effect of randomly-methylated-â-cyclodextrin (RAMEB) and polyvinylpyrrolidone (PVP) on the solubility of furosemide (FS) was studied. Different molar ratios (1:1, 1:2) and various preparation methods (physical mixing, kneading, ultrasonication) were used for the preparation of the complexes, and a quantity of 15% of PVP was added. The ternary inclusion complexes were analyzed by in vitro dissolution tests, differential scanning calorimetry, in vitro membrane diffusion and X-ray diffraction. The presence of RAMEB and PVP strongly influences different parameters of furosemide: solubility, dissolution, leading to the possibility of obtaining new pharmaceutical preparations, with a greater bioavailability.

Original languageEnglish
Pages (from-to)726-730
Number of pages5
JournalRevista de Chimie
Volume57
Issue number7
Publication statusPublished - júl. 2006

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ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science (miscellaneous)
  • Engineering(all)
  • Surfaces, Coatings and Films
  • Materials Chemistry

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