The immunosuppressive effect of acute doses of emetine on murine thymic cells

F. Antoni, N. N. Luat, I. Csuka, I. Oláh, A. Soóki-Tóth, G. Bánfalvi

Research output: Article

10 Citations (Scopus)

Abstract

Emetine - a general inhibitor of protein synthesis - was investigated for its ability to depress specific immune response in animal models. A single dose (33 mg/kg) of emetine administered subcutaneously to mice markedly decreased thymus weight and thymic cell numbers. DNA, RNA and protein synthesis of thymic cells were reduced by 90, 50 and 65%, respectively. RNA synthesis was the first process to recover followed by the reconstitution of DNA and protein synthesizing capacity. Histological evidence revealed an effect on the cortical region of thymus upon emetine administration. Results suggest that emetine exerts an immunosuppressive effect on T-cell maturation in the thymus. These findings may enhance a therapeutic interest in the drug.

Original languageEnglish
Pages (from-to)333-340
Number of pages8
JournalInternational Journal of Immunopharmacology
Volume9
Issue number3
DOIs
Publication statusPublished - 1987

Fingerprint

Emetine
Immunosuppressive Agents
Thymus Gland
RNA
Protein Synthesis Inhibitors
DNA
Proteins
Animal Models
Cell Count
T-Lymphocytes
Weights and Measures
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

The immunosuppressive effect of acute doses of emetine on murine thymic cells. / Antoni, F.; Luat, N. N.; Csuka, I.; Oláh, I.; Soóki-Tóth, A.; Bánfalvi, G.

In: International Journal of Immunopharmacology, Vol. 9, No. 3, 1987, p. 333-340.

Research output: Article

Antoni, F. ; Luat, N. N. ; Csuka, I. ; Oláh, I. ; Soóki-Tóth, A. ; Bánfalvi, G. / The immunosuppressive effect of acute doses of emetine on murine thymic cells. In: International Journal of Immunopharmacology. 1987 ; Vol. 9, No. 3. pp. 333-340.
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AU - Bánfalvi, G.

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