The first direct enzymatic hydrolysis of alicyclic β-amino esters: A route to enantiopure cis and trans β-amino acids

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The first direct enzymatic method is reported for the synthesis of cis and trans βamino acid enantiomers through the lipase-catalyzed enantioselective hydrolysis of alicyclic β esters in organic media. High enantioselectivities (E usually > 001) were observed when the Candida antarctica lipase B catalyzed reactions were performed with H2O (0.5 equivalents) in iP iPr2O at 5°C. The resolved products, obtained in good yields (≥42%), could be easily separated.

Original languageEnglish
Pages (from-to)6397-6401
Number of pages5
JournalChemistry - A European Journal
Issue number22
Publication statusPublished - aug. 8 2007


ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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