The effects of somatostatin and octreotide on the human sphincter of Oddi

Borbála Velõsy, László Madácsy, Attila Szepes, László Pávics, László Csernay, János Lonovics

Research output: Article

22 Citations (Scopus)

Abstract

Objective. Somatostatin acts at different sites in the human gastrointestinal tract and generally inhibits the release and effects of many gastrointestinal hormones and neuropeptides. Together with its long-acting analogue octreotide, somatostatin is widely used in the treatment of hormone-producing tumours, variceal bleeding, etc., but multi-centre trials have failed to prove a beneficial effect in the treatment of acute pancreatitis or in the prevention of post-ERCP pancreatitis (pancreatitis following endoscopic retrograde cholangiopancreatography). The aim of the present work was to study the effects of somatostatin and octreotide on the human sphincter of Oddi by means of quantitative hepatobiliary scintigraphy (QHBS). Method. Fifteen cholecystectomized patients were enrolled in the study, six in the somatostatin group and nine in the octreotide group. QHBS was performed initially with a standard protocol (baseline data), then repeated after 0.1 mg octreotide or a 250 μg bolus + 250 μg/h somatostatin administration. In the 60th min of QHBS, 0.5 mg glyceryl trinitrate (GTN) was administered sublingually. Results. QHBS demonstrated that both somatostatin and octreotide caused a marked impairment in the bile flow: the half-time of excretion (T(1/2)) over the common bile duct was significantly prolonged compared with baseline data (somatostatin group: common bile duct T(1/2) 180 min versus 59.7 ± 31 min; octreotide group: common bile duct T(1/2) 140.9 ± 60.5 min versus 30.7 ± 11.7 min). Glyceryl trinitrate administration accelerated the transpapillary bile flow, with significant decreases in the elevated T(1/2) in both groups. Conclusion. Increased transpapillary flow induced by glyceryl trinitrate may be beneficial in the treatment of acute or post-ERCP pancreatitis.

Original languageEnglish
Pages (from-to)897-901
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
Volume11
Issue number8
DOIs
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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