The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activity

Buket Bozkurt Sarikaya, Sevil Zencir, Nehir Unver Somer, Gulen Irem Kaya, Mustafa Ali Onur, Jaume Bastida, Agnes Berenyi, Istvan Zupko, Zeki Topcu

Research output: Article

17 Citations (Scopus)

Abstract

In this study, narciprimine and arolycoricidine were isolated from G. rizehensis Stern (Amaryllidaceae). The structures of the alkaloids were elucidated by spectroscopic methods (1D NMR, EI-MS). Due to the previous reports on anti-cancer activity of this group of alkaloids, we investigated their effects on DNA topoisomerase reactions, which are known as the cellular targets of a number of chemotherapeutical drugs. The results revealed that arolycoricidine and narciprimine were effective in both type I and type II DNA topoisomerase reactions in a dose-dependent manner. Topoisomerase-interfering ability of these alkaloids partially correlated with cytostaticity assays, using HeLa (cervix adenocarcinoma), MCF7 (breast adenocarcinoma) and A431 (skin epidermoid carcinoma) cells. Our results are discussed in relation to the potential significance of these alkaloids in the course of drug-development studies.

Original languageEnglish
Pages (from-to)381-385
Number of pages5
JournalRecords of Natural Products
Volume6
Issue number4
Publication statusPublished - júl. 20 2012

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Organic Chemistry

Fingerprint Dive into the research topics of 'The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activity'. Together they form a unique fingerprint.

  • Cite this

    Sarikaya, B. B., Zencir, S., Somer, N. U., Kaya, G. I., Onur, M. A., Bastida, J., Berenyi, A., Zupko, I., & Topcu, Z. (2012). The Effects of Arolycoricidine and Narciprimine on Tumor Cell Killing and Topoisomerase Activity. Records of Natural Products, 6(4), 381-385.