Objectives: To investigate how sample-storage alters thyroglobulin (Tg) and thyroglobulin-antibody (TgAb) immunoreactivity. Design and methods: Tg and TgAb measurements at different storage-times and -temperatures. Results: 48-h-storage at 4-10 °C (but not 8 h at room temperature) increased Tg and decreased TgAb immunoreactivity by maximum + 23% and - 16%. 4-weeks-storage at - 17 to - 20 °C decreased both Tg and TgAb by max. 21-31%. Conclusions: Storage of samples at 4-10 °C for > 24-48 h, or at - 17 to - 20 °C for > 2-3 weeks significantly alters Tg and TgAb immunoreactivity.
ASJC Scopus subject areas
- Clinical Biochemistry