The effect of intraperitoneally administered dimethyl sulfoxide on absence-like epileptic activity of freely moving WAG/Rij rats

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Abstract

Dimethyl sulfoxide (DMSO) is a widely used solvent for water-insoluble molecules and it has antioxidant, neuroprotective and cryopreservative effects. While DMSO is a regularly used solvent in research and a therapeutic agent, several cases of DMSO evoked seizures were reported in the literature. Therefore, we investigated the effect of different doses of DMSO on the absence-like epileptic activity of Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. We revealed that low doses of DMSO decreased whereas high doses of DMSO increased the absence-like epileptic activity of WAG/Rij rats.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalJournal of Neuroscience Methods
Volume197
Issue number1
DOIs
Publication statusPublished - ápr. 15 2011

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Dimethyl Sulfoxide
Therapeutic Human Experimentation
Neuroprotective Agents
Seizures
Antioxidants
Water

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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abstract = "Dimethyl sulfoxide (DMSO) is a widely used solvent for water-insoluble molecules and it has antioxidant, neuroprotective and cryopreservative effects. While DMSO is a regularly used solvent in research and a therapeutic agent, several cases of DMSO evoked seizures were reported in the literature. Therefore, we investigated the effect of different doses of DMSO on the absence-like epileptic activity of Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. We revealed that low doses of DMSO decreased whereas high doses of DMSO increased the absence-like epileptic activity of WAG/Rij rats.",
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T1 - The effect of intraperitoneally administered dimethyl sulfoxide on absence-like epileptic activity of freely moving WAG/Rij rats

AU - Kovács, Z.

AU - Czurkó, A.

AU - Kékesi, K.

AU - Juhász, G.

PY - 2011/4/15

Y1 - 2011/4/15

N2 - Dimethyl sulfoxide (DMSO) is a widely used solvent for water-insoluble molecules and it has antioxidant, neuroprotective and cryopreservative effects. While DMSO is a regularly used solvent in research and a therapeutic agent, several cases of DMSO evoked seizures were reported in the literature. Therefore, we investigated the effect of different doses of DMSO on the absence-like epileptic activity of Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. We revealed that low doses of DMSO decreased whereas high doses of DMSO increased the absence-like epileptic activity of WAG/Rij rats.

AB - Dimethyl sulfoxide (DMSO) is a widely used solvent for water-insoluble molecules and it has antioxidant, neuroprotective and cryopreservative effects. While DMSO is a regularly used solvent in research and a therapeutic agent, several cases of DMSO evoked seizures were reported in the literature. Therefore, we investigated the effect of different doses of DMSO on the absence-like epileptic activity of Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. We revealed that low doses of DMSO decreased whereas high doses of DMSO increased the absence-like epileptic activity of WAG/Rij rats.

KW - Absence epilepsy

KW - DMSO

KW - WAG/Rij rats

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