The authors simultaneously studied the physico-chemi- cal properties of rat tail tendon (amount of labile hydroxyproline, changes of thermo-isometric tension) and uterine collagen (collagen content, total hydroxyproline, labile hydroxyproline ratio) during the biological ageing of control animals and experimental animals of identical age, exposed to long-lasting stressful stimulation. Similar changes to the tail tendon were found in the uterine collagen. The Stress localisation of increased uterine collagen production under the given experimental conditions, besides the fibroblasts, was partly found in the smooth muscle cells transformed to fibroblastic direction as revealed by electron microscopic investigation of the myometrium.
ASJC Scopus subject areas
- Geriatrics and Gerontology