E-N-l-Trimethyllysine glutamate (TML) influences the humoral and cellular immune response of mice. Chronic pre- and post-treatment (100 mg/kg/day, 5 times) transitionally increased the anti-SRBC haemagglutinin titre of female CBA mice. After 400 r whole body irradiation, TML treatment accelerated the normalization of the haemagglutinin level. TML treatment prolonged the life-span of BDF1 hybrid mice that had first been immunized and then inoculated with L1210 cells. TML diminished the delayed type hypersensitivity mice and dosse-dependently decreased the spontaneous (SLMC) and antibody-dependent (ADCC) cytotoxicity of healthy human lymphocytes, in vitro. As a low molecular weight immunomodulant, TML may also be considered as a therapeutic tool.
ASJC Scopus subject areas
- Pharmacology (medical)