A KRIOGLOBULINOK: PATOLOGIAS AUTOANTITESTEK VAGY KULONLEGES VEDOFEHERJEK?

F. Uher, E. J. Puskas, J. Cervenak

Research output: Article

Abstract

Cryoglobulins are usually defined as pathological immunoglobulins which precipitate or form gel below 37 °C. On the immunochemical properties the purified cryoglobulins can be classified into three groups. Type I cryoglobulins, being monoclonal immunoglobulins, are found almost exclusively in patients with malignant B cell tumors. Type II ones are complexes of a monoclonal IgG specific component, and a polyclonal IgG. Type III ones are mixed cryoglobulins composed of one or more classes of polyclonal immunoglobulins in the form of immunoglobulin-anti-immunoglobulin complexes. These are usually characteristic to an immune complex disease, e.g. systemic lupus, rheumatoid arthritis or chronic infection. Small amounts of cryoglobulin (about 30 mg-1), however, also occur in the normal human serum. The question is, whether there is a functional significance of these 'natural' cryoglobulins in the homeostasis and/or in the etiology of cryoglobulinaemias? A theory dealing with these questions is presented. The speculation is mostly based on the considerations offered by the immunological homunculus model.

Original languageHungarian
Pages (from-to)190-195
Number of pages6
JournalLege Artis Medicinae
Volume6
Issue number3-4
Publication statusPublished - 1996

Fingerprint

Cryoglobulins
Autoantibodies
Immunoglobulins
Proteins
Immunological Models
Immunoglobulin G
Immune Complex Diseases
Cryoglobulinemia
Immunoglobulin Isotypes
Rheumatoid Arthritis
Homeostasis
B-Lymphocytes
Gels
Infection
Serum
Neoplasms

Keywords

  • cryoglobulins
  • idiotypic network
  • natural autoantibodies
  • systemic autoimmune diseases

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A KRIOGLOBULINOK : PATOLOGIAS AUTOANTITESTEK VAGY KULONLEGES VEDOFEHERJEK? / Uher, F.; Puskas, E. J.; Cervenak, J.

In: Lege Artis Medicinae, Vol. 6, No. 3-4, 1996, p. 190-195.

Research output: Article

Uher, F, Puskas, EJ & Cervenak, J 1996, 'A KRIOGLOBULINOK: PATOLOGIAS AUTOANTITESTEK VAGY KULONLEGES VEDOFEHERJEK?', Lege Artis Medicinae, vol. 6, no. 3-4, pp. 190-195.
Uher, F. ; Puskas, E. J. ; Cervenak, J. / A KRIOGLOBULINOK : PATOLOGIAS AUTOANTITESTEK VAGY KULONLEGES VEDOFEHERJEK?. In: Lege Artis Medicinae. 1996 ; Vol. 6, No. 3-4. pp. 190-195.
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