The complex role of vitamin D in autoimmune diseases

P. Szodoray, B. Nakken, J. Gaál, R. Jonsson, A. Szegedi, E. Zold, G. Szegedi, J. G. Brun, R. Gesztelyi, M. Zeher, E. Bodolay

Research output: Article

142 Citations (Scopus)

Abstract

Vitamin D, besides having well-known control functions of calcium and phosphorus metabolism, bone formation and mineralization, also has a role in the maintenance of immune-homeostasis. The immune-regulatory role of vitamin D affects both the innate and adaptive immune system contributing to the immune-tolerance of self-structures. Impaired vitamin D supply/regulation, amongst other factors, leads to the development of autoimmune processes in animal models of various autoimmune diseases. The administration of vitamin D in these animals leads to improvement of immune-mediated symptoms. Moreover, in human autoimmune diseases, such as multiple sclerosis, or rheumatoid arthritis the pathogenic role of vitamin D has been described. The review aims at describing the complex immune-regulatory role of vitamin D from the cellular level through autoimmune animal models and depicting the known contribution of vitamin D in the pathogenesis of human autoimmune diseases.

Original languageEnglish
Pages (from-to)261-269
Number of pages9
JournalScandinavian Journal of Immunology
Volume68
Issue number3
DOIs
Publication statusPublished - szept. 2008

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Vitamin D
Autoimmune Diseases
Animal Models
Physiologic Calcification
Immune Tolerance
Antigen-Antibody Complex
Osteogenesis
Phosphorus
Multiple Sclerosis
Immune System
Rheumatoid Arthritis
Homeostasis
Maintenance
Calcium

ASJC Scopus subject areas

  • Immunology

Cite this

The complex role of vitamin D in autoimmune diseases. / Szodoray, P.; Nakken, B.; Gaál, J.; Jonsson, R.; Szegedi, A.; Zold, E.; Szegedi, G.; Brun, J. G.; Gesztelyi, R.; Zeher, M.; Bodolay, E.

In: Scandinavian Journal of Immunology, Vol. 68, No. 3, 09.2008, p. 261-269.

Research output: Article

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AU - Szegedi, G.

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