Nem szteroid gyulladáscsökkentôk cardiovascularis kockázata

C. Ambrus, István Kiss

Research output: Article


Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most common pain relief and anti-inflammatory medications all over the World, and many formulations are also available over-the-counter. Beyond the well-known gastrointestinal risks, emerging evidence supports increased incidence of cardiovascular events associated with the use of NSAIDs. This cardiovascular risk seems to be independent of the cyclooxygenase selectivity of these drugs. Distinct side effect profiles of various NSAIDs were summarized in a former issue of the Journal: LAM 2014;24(7):327. In this paper, we aimed to summarize some of the yet unpublished results of a major research project of the European Medicines Agency (EMA), that was conducted in order to establish the relative risk of CV outcomes (myocardial infarction, ischa-emic stroke and hospitalization for heart failure) associated with the use of various NSAIDs. In this epidemiological study, seven European healthcare databases on a source population of 35 million subjects were linked and analyzed. Most of the results are currently only available on the project homepage; however, analyses of heart failure data have already been published in a recent issue of The BMJ.

Translated title of the contributionThe cardiovascular risk of nonsteroidal antiinflammatory drugs
Original languageHungarian
Pages (from-to)497-502
Number of pages6
JournalLege Artis Medicinae
Issue number11-12
Publication statusPublished - 2016


  • Cardiovascular risk
  • Gastrointestinal risk
  • Nonsteroidal antiinflammatory drugs

ASJC Scopus subject areas

  • Medicine(all)

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